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Hua Lu, Ph.D.

Associate Professor

Hua Lu

Office: BS 415
Phone: 410-455-5972
Lab: BS 411/412
Lab Phone: 410-455-2263
Email: hualu@umbc.edu

Research Group

Education

Postdoctoral, The University of Chicago, 2005
Ph.D., Texas A&M University, 1999

Professional Interests

Arabidopsis infected with Pseudomonas

Arabidopsis infected with Pseudomonas

Pathogen-induced plant diseases are among the greatest deterrents to agriculture worldwide. Properly regulated defense signaling networks are critical for the fitness of plants. However, it remains challenging to identify which genes regulate plant innate immunity, decipher how these genes affect antimicrobial activities, and determine how the defense regulatory networks are coordinated.

We exploit the powerful model system Arabidopsis thaliana in our investigations of mechanisms of plant innate immunity. Arabidopsis is a small herbaceous plant that can be easily grown within limited space. It has a short life cycle and extremely well characterized genetics. In addition, Arabidopsis has a relatively small, fully sequenced genome, and can be easily manipulated at the physiological, genetic and molecular levels. As all higher plants are believed to share similar innate immunity, knowledge on defense mechanisms obtained from Arabidopsis can be readily applied to other plants and enable us to better control diseases in agriculturally important crops.

Publications

Hua Lu, Jean T. Greenberg, and Loreto Holuigue (2016). Editorial: salicylic acid signaling networks. Front Plant Sci 7, 238. [PubMed]

Safae Hamdoun, Chong Zhang, Manroop Gill, Narender Kumar, Michelle Churchman, John C. Larkin, Ashley Kwon, and Hua Lu (2016). Differential roles of two homologous cyclin-dependent kinase inhibitor genes in regulating cell cycle and innate immunity in Arabidopsis. Plant Physiol 170, 515-527. [Abstract]

Guoying Wang*, Chong Zhang*, Stephanie Battle, and Hua Lu (2014) The phosphate transporter PHT4;1 is a salicylic acid regulator likely controlled by the circadian clock protein CCA1. Front. Plant Sci., doi: 10.3389/fpls.2014.00701. [Abstract]

* These authors contributed equally to this work.

Safae Hamdoun, Yi Liu, Manroop Gill, Nan Yao, and Hua Lu (2013) Dynamics of defense responses and cell fate change during Arabidopsis-Pseudomonas syringae interactions. PLoS ONE 8(12): e83219. doi: 10.1371/journal.pone.0083219. (http://www.ncbi.nlm.nih.gov/pubmed/24349466)

Wang Xu, Ross Sager, Weier Cui, Chong Zhang, Hua Lu, and Jung-Youn Lee (2013) Salicylic acid represses cell-to-cell communication during innate immune responses in Arabidopsis. Pant Cell, in press.

Chong Zhang, Qiguang Xie, Gina Ng, Ryan G. Anderson, Nick Seitz, Thomas Peterson, C. Robertson McClung, John M. McDowell, Dongdong Kong, June M. Kwak, and Hua Lu (2013) Crosstalk between the circadian clock and innate immunity in Arabidopsis. PLoS Pathogens 9: e1003370. (Selected as the top featured research)

Hua Lu, Chong Zhang, Ute Albrecht, Rena shimizu, Guanfeng Wang, Kim Bowman (2013) Overexpression of a citrus NDR1 ortholog increases disease resistance in Arabidopsis. Frontiers in Plant Science 4 (157).

Gina Ng*, Savanna Seabolt*, Chong Zhang, Sasan Salimian, Timley A. Watkins, Hua Lu (2011)  Genetic dissection of salicylic acid-mediated defense signaling networks in Arabidopsis. Genetics 189(3): 851-9.

* These authors contributed equally to this work.
[Abstract]

Jung-Youn Lee, Xu Wang, Weier Cui1, Ross Sager, Shannon Modla, Boris Zybaliov, Klaas van Wijk, Chong Zhang, Hua Lu, Kirk Czymmek and Venkatachalam Lakshmanan (2011) A plasmodesmata-localized protein mediates a crosstalk between cell-to-cell communication and innate immunity in Arabidopsis.  Plant Cell 23(9):3353-73.
[Abstract]

Wang GF, Seabolt S, Hamdoun S, Ng G, Park J, Lu H. (2011) Multiple Roles of WIN3 in Regulating Disease Resistance, Cell Death, and Flowering Time in Arabidopsis. Plant Physiology 156: 1508-1519.
[Abstract]

Wang GY, Shi JL, Ng G, Battle SL, Zhang C, Lu H. (2011) Circadian Clock-Regulated Phosphate Transporter PHT4;1 Plays an Important Role in Arabidopsis Defense. Molecular Plant 4: 516-526.
[Abstract]

Lee Jung-Youn, Hua Lu (2011) Plasmodesmata: the battleground against intruders. Trends in Plant Sci. 16: 201-210.
[Abstract]

Hua Lu  (2009) Dissection of salicylic acid-mediated defense signaling networks. Plant Signaling & Behavior . (Review)
[Abstract]

Hua Lu, Sasan Salimian, Emily Gamelin, Guoying Wang, Jennifer Fedorowski, William LaCourse, Jean T. Greenberg (2009) Genetic analysis of acd6-1 reveals complex defense networks and leads to identification of novel defense genes in Arabidopsis. Plant J. 58(3): 401-12
[Abstract]

Ruth K. Genger, Grace I. Jurkowski, John M. McDowell, Hua Lu, Ho Won Jung, Jean T. Greenberg, Andrew F. Bent  (2008) Signaling pathways that regulate the enhanced disease resistance of Arabidopsis “defense, no death” mutants. Molecular Plant-Microbe Interactions 21(10):1285-96.
[Abstract]

Min Woo Lee, Hua Lu, Ho Won Jung, Jean T. Greenberg (2007) A key role for the Arabidopsis WIN3 protein in disease resistance triggered by Pseudomonas syringae that secrete AvrRpt2. Molecular Plant-Microbe Interactions 20(10): 1192-1200.
[Abstract]

Hua Lu, Yang Liu, Jean T. Greenberg (2005) Structure-functional analysis of the plasma membrane-localized Arabidopsis defense component ACD6. Plant Journal 44(5):798-809.
[Abstract]

Hua Lu, Elizabeth Gorman, Thomas D. McKnight (2005) Molecular characterization of two anthranilate synthase alpha subunit genes in Camptotheca acuminata. Planta 221(3): 352-60.
[Abstract]

Jong Tae Song, Hua Lu, John M. McDowell, Jean T. Greenberg (2004) A key role for ALD1 in activation of local and systemic defenses in Arabidopsis. Plant Journal 40: 200-212.
[Abstract]

Jong Tae Song, Hua Lu, Jean T. Greenberg (2004) Divergent roles in Arabidopsis development and defense of two homologous genes, aberrant growth and death2 and AGD2-LIKE DEFENSE RESPONSE PROTEIN1, encoding novel aminotransferases. Plant Cell 16 (2): 353-66.
[Abstract]

Hua Lu, Debra N. Rate, Jong Tae Song, Jean T. Greenberg (2003) ACD6, a novel ankyrin protein, is a regulator and an effector of salicylic acid signaling in the Arabidopsis defense response.  Plant Cell 15 (10): 2408-20.
[Abstract]

Hua Liang, Nan Yao, Jong Tae Song, Song Luo, Hua Lu, Jean T. Greenberg (2003) Ceramides modulate programmed cell death in plants. Genes and Development 17 (21): 2636-41
[Abstract]

Helene Vanacker*, Hua Lu*, Debra N. Rate, Jean T. Greenberg (2001) A role for salicylic acid and NPR1 in cell fate determination in Arabidopsis. Plant Journal 28: 209-216. (* These authors contributed equally).
[Abstract]

Hua Lu, Ming Chen, Allan M. Showalter (2001) Developmental expression and perturbation of arabinogalactan proteins during seed germination and seedling growth in tomato. Physiologia Plantarum 112: 442-450.
[Abstract]

Hua Lu and Thomas D. McKnight (1999) Tissue-specific expression of the beta-subunit of tryptophan synthase in Camptotheca acuminata, an indole alkaloid-producing plant. Plant Physiology 120: 43-51.
[Abstract]

Courses Taught

BIOL 456: Plant Molecular Biology
BIOL 656: Plant Molecular Biology
BIOL 750: Graduate Seminar: Advanced Topics in Organismic Biology