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Undergraduate Course Information

BIOL 101 Concepts of Biology

A broad overview of contemporary biological science. Major areas include the biochemistry of energy transformation, cell structure and function, Mendelian, molecular and population genetics, development and differentiation, plant and animal physiology, evolution, and ecology. This introductory Biology course is designed for non-majors and may not be used towards the BIOL, BIOC or BINF degrees. Prerequisite: High School Biology and Chemistry. Science (non-lab) (GEP), Science (non-lab) (GFR) [4]

FYS 101-I First Year Seminar. Science Versus Religion: The Battle of Evolution

This interdisciplinary course aims to illustrate the sheer breadth of disciplines across which a dialog can occur about science and religion, to introduce historical examples of dialog that challenge dogma from extremists of all persuasions who preach oversimplified “either/or” conflict, and to understand the origin, construction, and impact of science and religion on society. Arts and Humanities (GEP), Arts and Humanties (GFR) [3]

This interdisciplinary course aims to illustrate the sheer breadth of disciplines across which a dialog can occur about science and religion, to introduce historical examples of dialog that challenge dogma from extremists of all persuasions who preach oversimplified “either/or” conflict, and to understand the origin, construction, and impact of science and religion on society. Arts and Humanities (GEP), Arts and Humanties (GFR) [3]

FYS 103-C First Year Seminar. Issues in Biotechnology (MS)

Through directed readings, class discussions, and student presentations, this seminar will focus on understanding these various aspects of modern biotechnology with an emphasis on its scientific basis. Practical demonstrations and visits to UMBC labs using biotechnological techniques will be an important part of the course to illustrate how the methods theoretically discussed in class are actually done. Science (non-lab) (GEP), Science (non-lab) (GFR) [3]

BIOL 106 The Human Organism

This course is designed to introduce the non-science student to science and its methods and provide a basic understanding of some body functions and dysfunctions. Topics include genes and DNA, cells and cancer, immune system and HIV, metabolism and nutrition, muscles and exercise, nervous system and drugs, etc. Recommended: High school biology and chemistry. Science (non-lab) (GEP), Science (non-lab) (GFR) [3]

BIOL 107 Biology of Cancer

A major killer disease in Western countries will be examined from the biological perspective. This course will evaluate current epidemiologic, clinical and experimental research and assess the relative importance of environmental and genetic factors as they relate to the causes and prevention of this disease. Particular emphasis will be given to unraveling the links between dietary and nutritional factors and this “disease of affluence.” Note: Formerly listed as BIOL 103D. Prerequisite: Some background in the natural sciences, preferably one year in both high school biology and chemistry. Not open to BIOL and BIOCHEM majors. Science (non-lab) (GFR) [3]

BIOL 108 Biology of Heart Disease

This course will develop, from a biological perspective, the nature of heart disease and the complex connections between environmental factors and this life-threatening illness. We specifically will consider the current, often conflicting, evidence that links dietary factors with the onset of the disease. Science (non-lab) (GFR) [3]

BIOL 109 Life: Introduction to Modern Biology

This is a lab-driven course designed to fulfill the university graduation requirement of a science lab. Topics covered will include basic biological concepts such as the nature of DNA, heredity, human genetics and the process of mutation, as well as modern issues such as forensic analysis of DNA and blood, the biology behind cancer and genetic diseases, and others as determined by current events and interest. The course includes a 75-minute lecture and 180-minute lab. Course Fee = $50.00, Science Plus Lab (GEP), Science Plus Lab (GFR) [3]

BIOL 123 Human Genetics

A course designed for non-biology majors. Topics will include the fundamental rules of heredity, gene structure and function, human genetic diseases and genetic engineering. Particular emphasis will be placed on the application of the new genetic technology to the human condition. Science (non-lab) (GEP), Science (non-lab) (GFR) [3]

BIOL 123L Basic Genetics Laboratory

Lab Component (must be paired with S course) (GEP), Lab Component (must be paired with S course) (GFR) [1]

BIOL 141 Foundations of Biology: Cells, Energy and Organisms

This course for majors provides a broad overview of contemporary biological concepts. Major topics include structure and synthesis of nucleic acids and proteins, molecular genetics, prokaryotic and eukaryotic cell structure and function, biochemistry of energy transformation, and animal and plant development and physiology. This course is designed to prepare students for upper level biology core and elective courses. It is one of two introductory courses (BIOL 141 & 142) designed exclusively for BIOL, BIOC and BINF majors; either course can be taken first. Pre- or co-requisite: MATH 150 or equivalent. Science (non-lab) (GEP), Science (non-lab) (GFR) [4]

BIOL 141H Foundations of Biology: Cells, Energy and Organisms – Honors

This course for majors provides a broad overview of contemporary biological concepts. Major topics include structure and synthesis of nucleic acids and proteins, molecular genetics, prokaryotic and eukaryotic cell structure and function, biochemistry of energy transformation, and animal and plant development and physiology. This course is designed to prepare students for upper level biology core and elective courses. It is one of two introductory courses (BIOL 141 & 142) designed exclusively for BIOL, BIOC and BINF majors; either course can be taken first. Pre- or co-requisite: MATH 150 or equivalent. Science (non-lab) (GEP), Science (non-lab) (GFR). [4]

BIOL 142 Foundations of Biology: Ecology and Evolution

This course provides a broad overview of contemporary biological concepts. Major topics include fundamental concepts in ecology and evolution and emphasizes the fundamental interrelationship between these two fields of study. Concepts in evolution include a general description of the diversity of life, a review of Mendelian genetics, the causes and consequences of speciation, natural selection and genetic drift. Concepts in ecology will focus on ecological and evolutionary factors that govern population growth and regulation, species distributions, community and ecosystem ecology. This course is designed to prepare students for upper level biology core and elective courses. It is one of two introductory courses (BIOL 141 & 142) designed exclusively for BIOL, BIOC and BINF majors. Recommended Preparation: MATH 150 or equivalent. [4]

BIOL 215H eBiology – Phage Hunters I

This is a lab-driven course for students not majoring in natural or physical sciences. Participants will engage in genuine, real-world research identifying novel bacteriophages from the environment using modern biological techniques. The course includes two lab meetings per week and a large degree of self-paced investigative work. The lab continues with HONR216 eBiology – Phage Hunters II. No science background is required. Science Plus Lab (GEP), Science Plus Lab (GFR). Requirement Group: You must have been admitted to the Honors College to take this course. [3]

BIOL 216H eBiology – Phage Hunters II

In Phage Hunters II, participants will utilize state of the art computer programs to annotate a complete bacteriophage genome sequence generated in HONR 215/BIOL215H, and identify that unknown bacteriophage. The course includes two lab meetings per week and a large degree of self-paced investigative work. No science background is required. Prerequisites: HONR215/BIOL215H. Science Plus Lab (GEP), Writing Intensive, Science Plus Lab (GFR). [3]

BIOL 233 Nutrition and Health

Basic principles of normal human nutrition. Topics include: nutrient classification; digestion, assimilation, and metabolic functions of the major nutrients; energy balance; metabolic regulation; dietary guidelines and standards; nutrient composition of foods and diet selection; nutritional considerations in pregnancy, childhood, adulthood, and later years. This course provides an introduction to nutrition for students pursuing careers in health-related fields. Prerequisite: BIOL 100 or BIOL 100H, or BIOL 101 or BIOL 141 or BIOL 141H AND CHEM102 or CHEM 102H or CHEM 124 all of which has to have a grade of C or better [3]

BIOL 251 Human Anatomy and Physiology I

The first semester of a two-semester lecture course covering the structure and function of the organs of the human body. An integrated approach permits concurrent presentation of the anatomy and physiology of each organ system. Prerequisites: BIOL 100 or 100H or 101 or 141 or 141H and CHEM 124 or 102 or 102H or permission of the instructor. All prerequisites must be completed with a grade of C or better. Science (non-lab) (GFR) [3]

BIOL 251L Human Anatomy and Physiology I Laboratory

Laboratory course to accompany BIOL 251. The laboratory includes dissections, work with skeletons. models of body parts. and experimental studies of physiological processes. Required for most Allied Health programs. Prerequisites: CHEM 124L or CHEM 102L. Pre- or Corequisite: BIOL 251 or equivalent, or permission of the instructor. All prerequisites must be completed with a grade of C or better. Course Fee = $50.00, Lab Component (must be paired with S course) (GEP), Lab Component (must be paired with S course) (GFR) [1]

BIOL 252 Human Anatomy and Physiology 11 (MS)

Continuation of BIOL 251. You must have completed BIOL 251 with a grade of C or better, or permission of instructor. Science (non-lab) (GFR) [3]

BIOL 252L Human Anatomy and Physiology II Laboratory

Continuation of BIOL 251L. Prerequisite: You must have completed BIOL 251 with a grade of C or better, or permission of instructor. All prerequisites must be completed with a grade of C or better. Course Fee = $50.00, Lab Component (must be paired with S course) (GEP), Lab Component (must be paired with S course) (GFR) [1]

BIOL 275 Microbiology

Introductory course describing the fundamental properties of micro-organisms and viruses and their relationships to other life forms. Topics include the structure and function of bacteria, mode of action of antibiotics, genetics of bacteria and the role of bacteria in disease. The structure, replication and pathology of viruses are discussed, including the response of hosts to viral infection and the fundamental concepts of the immune response. Prerequisite: BIOL 100, BIOL 100H, BIOL 101, BIOL 141 or BIOL 141H. Science (non-lab) (GEP), Science (non-lab) (GFR). [3]

BIOL 275L Microbiology Laboratory

This laboratory course consists of a series of exercises designed to familiarize the student with microbiological techniques. Experiments are performed in basic bacteriology. applied bacteriology, virology and immunology. Students will be expected to work independently. spending brief periods of time other than during the scheduled lab period collecting data. Pre- or corequisite: BIOL 275. Course Fee = $50.00, Lab Component (must be paired with S course) (GEP), Lab Component (must be paired with S course) (GFR). [2]

BIOL 300L Experimental Biology Laboratory

An upper level course of experiments designed to give students the essential laboratory and critical thinking skills in experimental design, implementation and analysis that every biologist should know. This knowledge base is required for succeeding in further BIOL laboratory courses and for working in a research laboratory. Required of all BIOL majors and a prerequisite for all upper level BIOL laboratory courses. Prerequisites: CHEM 102, CHEM 102L and BIOL 302. [2]

BIOL 301 Ecology and Evolution (MS)

An introduction to the processes of evolution, the outcomes of evolution, and the field of ecology. Processes of evolution include understanding natural selection, genetic drift, molecular evolution and general evolutionary theory. Outcomes of evolution include speciation, hybridization, building phylogenetic trees, and using trees to understand the diversity of life, especially vertebrate evolution. Ecology topics include population growth and regulation, competition, predator/prey interctions, symbiosis, community structure and food webs, and energy flow and nutrient cycling within ecosystems. Prerequisite: BIOL 142 [4]

BIOL 302 Molecular and General Genetics

Modern principles of heredity have been established through studies at the molecular, cellular and organismic levels. The course includes fundamental information on the structure of a gene, its expression and organization as deduced from analysis of viral and prokaryotic systems, the transmission of genetic material in eukaryotic systems,the interaction of genes in populations and the application of fundamental genetic principles to problems of human heredity. Prerequisite: BIOL 100 or BIOL 141, BIOL 142 or BIOL 301, and CHEM 101 or 123. Co-requisite: CHEM 102 or 124. Science (non-lab) (GEP), Science (non-lab) (GFR) [4]

BIOL 302L Molecular and General Genetics Laboratory

A laboratory course designed to illustrate fundamental genetic principles by experimentation. Such principles include the nature of genetic material, transfer of genetic information in prokaryotic and eukaryotic systems, organization and regulation of gene expression, Mendel’s rules of heredity, linkage and crossing over, and genetic variation. Students will be expected to work independently, spending periods of time other than during the scheduled lab period collecting data. Prerequisite: BIOL 300L and BIOL 302. [2]

BIOL 303 Cell Biology

A modern treatment of cell structure and function with emphasis on the molecular architecture, biochemistry and regulatory mechanisms common to all cells. Topics include membrane structure, function and transport; molecular mechanisms of energy metabolism and its associated organelles; the structural and molecular basis for the expression of genetic information; the organelles involved in the regulation of cell shape and motility; selected cell functions, growth, reproduction and their control. This course is designed for students interested in the biological sciences, biochemistry and the allied health professions. Prerequisites: BIOL 302, CHEM 102; CHEM 351 strongly recommended. [3]

BIOL 304 Plant Biology

A consideration of the basic physiology and development of plants. Topics include plant diversity, patterns of growth and development, the interaction between nuclear and cytoplasmic genomes, chloroplast development, photosynthesis, seed development, tissue differentiation, hormonal regulation, nitrogen fixation, tissue culture and plant tumors. Prerequisite: BIOL 303. [3]

BIOL 304L Plant Biology Laboratory

Basic plant biology will be explored through experiments, examination of live and preserved specimens, and lectures. Experiments will include photosynthesis, water relations, growth regulator effects, and interactions with bacteria. Prerequisite: BIOL 303L and BIOL 304. [2]

BIOL 305 Comparative Animal Physiology

Functional features of whole organisms and their component organs and organ systems will be studied. Emphasis will be on ways in which diverse organisms at various phylogenetic levels perform similar functions. Examples of topics include osmoregulation, gas exchange, control systems, sensors, effectors, brain and behavior. Prerequisite: BIOL 303. Pre- or Corequisite: PHYS 112. [3]

BIOL 305L Comparative Animal Physiology Laboratory

A laboratory designed to study experimentally selected organismic functions discussed in BIOL 305. Prerequisite: BIOL 303L. Pre- or Corequisite: PHYS 112 and BIOL 305. [2]

BIOL 306 Molecular Biology

This is an intermediate level course in molecular biology of prokaryotes, eukaryotes and their viruses. It will cover the principles governing the molecular mechanisms that occur in living cells including regulatory mechanisms. Topics will include the processing of genetic information through the central dogma (transcription, RNA processing and translation), DNA replication, mutation and DNA repair, and genomics. Recommended Course Preparation CHEM 351 and CHEM 352. [4]

BIOL 306L Projects in Molecular Biology

In this course students will conduct an open-ended investigation to discover the function of a gene. During the course of the investigation you will learn the basic techniques used to isolate a gene, move it into a suitable host organism, modify it and determine its function. All projects will give students experience with cell culture, cloning, PCR, DNA sequencing and computer-based DNA sequence analysis. Prerequisites: completion of Biol 300L and Biol 302 and Biol 303. [2]

BIOL 312L Modeling in the Life Sciences

Humans possess a superior ability to generate new knowledge by creating and manipulating abstract models of the world and by extrapolating from past experiences. This natural ability reaches its full potential when it is enhanced with the tools of experimental design, mathematics, logic, and computer simulation. BIOL 312L will be offered as a practical guide to creating and using models in the context of life sciences laboratory research. It will include classroom lectures, activities and computer applications intended to illustrate and implement the five basic elements of modeling: experimental design, data acquisition, analysis, model formulation, and simulation. Through the course, students will address a minimum of four concrete biological problems by defining key physical quantities to be measured, applying data visualization techniques to uncover trends, drawing statistically valid inferences, formulating algebraic and analytical models, and performing computer simulations. May be used as an upper level elective for the BA or BS in Biological Sciences. Prerequisites: BIOL 300L and Either STAT 350, MATH 151 or MATH 155. [2] BIOL312L – Modeling in the Life Sciences

BIOL 313 Introduction to Bioinformatics and Computational Biology

This is an introductory course to the field of Bioinformatics and Computational Biology, an emerging interdisciplinary field dealing with the application of computing methods in biology. The course will provide a brief introduction to contemporary molecular biology and evolutionary theory. It will introduce the concept of bioinformatics, its applications and its career opportunities. Applying a question/answer approach, it will then explore some of the main problems faced by biology in the last decades (such as genome sequencing and annotation or sequence-based search) and it will analyze in depth some of the computational methods provided by the emerging field of Bioinformatics. Lecture content will be complemented with home¿based assignments. No prior programming skills or biology knowledge are strictly required, but students are expected to have basic knowledge in either molecular biology or algorithmic techniques, and to acquire complementary knowledge within the course. The course is intended for a multidisciplinary audience with an emphasis on BINF, CMSC, BIOL, MATH, STAT and IS majors. Prerequisites: MATH 151 and either BIOL 141 or CMSC 104 (or equivalent). [3]

BIOL 340L Developmental Biology Laboratory

This laboratory is designed to give students exposure to the different techniques and organisms commonly used in Cell and Developmental Biology research. We will be working with a variety of live embryos, such as Drosophila, zebrafish, C. elegans, chicken, and axolotl. The major concepts that we will focus on include: gene regulation, both at the nucleotide level and at the chromatin level; pattern formation and cell-signaling; cell migration and cell-cell adhesion; and cell fate determination. The laboratory exercises will allow students to observe normal early embryonic development as well as experimentally manipulate embryos at different stages of early development. By comparing and contrasting these two situations, along with class discussions, students will further their understanding of many of the basic cellular and developmental processes seen in multicellular organisms. Prerequisites: BIOL 100L or 300L and BIOL 303 both with a grade of C or better. [2]

BIOL 390 Introduction to the Honors University for Transfer Students in the Life Sciences

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BIOL 395 MARC U*STAR Writing in the Sciences

Students in this course will examine and produce the basic forms of professional writing encountered in science careers. They will critique the work of their peers, and learn to analyze scientific literature. Specific assignments include writing review articles, CVs and personal statements for graduate school and funding agencies. This course does not fulfill Writing Intensive (WI) requirements. [2]

BIOL 396 Undergraduate Teaching Assistantship

This service-learning course is designed for undergraduate teaching assistants in biology courses. Students must be recommended in writing by the faculty member teaching the course and be approved by the department. Student work (either paid or volunteer) must be performed in a course taught by a full-time member of the biology department faculty and must have a significant learning component. To qualify, students must have a minimum 3.50 GPA in all biology courses taken (including repeated biology courses). In addition to their teaching responsibilities, students will attend a mandatory weekly session on effective teaching methods taught by a member of the biology faculty. P/F grading only, one credit will be earned for the mandatory weekly session and one credit for each 40 hours of qualified work during an academic semester. A maximum of four credits of BIOL 396 is allowed. Recommended Preparation: Junior standing, BIOL 100 and 100L (or equivalent), plus nine credits of 300-level BIOL courses and permission of the department [2-3]

BIOL 397 Ethics and Integrity in Scientific Research

Individuals involved in contemporary scientific research have ethical responsibilities for their conduct. The goal of this course is to provide students considering a career in scientific research with aframework for establishing appropriate scientific integrity. A variety of relevant topics will be discussed, including fraud and misconduct, peer review, obligations and rights of students and mentors, ethical conduct in animal and human experimentation, ownership of data, reagents, intellectual property, authorship and conflict of interest. Note: Permission of course coordinator required. [1]

BIOL 397H Honors Seminar

This course is designed for and required of those students seeking Departmental Honors in Biological Sciences. It is a series of weekly discussions designed to introduce undergraduate students to current biological research opportunities at UMBC in both the laboratory and the field. There will be a particular emphasis on the research areas currently being pursued by the Biological Sciences faculty. Each week a member of the faculty will lead a discussion of a specific re search area. Students will be assigned relevant readings prior to class and will be expected to participate in class discussion. The course is designed to prepare the student for an Honors re search project. Prerequisites: The student must meet eligibility requirements for the Honors Program in Biological Sciences, and receive permission to register from the Departmental Honors Program advisor. [3]

BIOL 398 Co-op Internship in the Biological Sciences

This course is designed for UMBC degree seeking students who are employed outside of the university as volunteers or for compensation, provided the following criteria are met: 1) the work must be performed at an institution, agency or company which is a participating employer in UMBC’s Cooperative Education Program, and 2) the work performed by the student must have a significant learning component in the biological sciences as judged by the Biological Sciences Internship Coordinator in consultation with the faculty of the Department of Biological Sciences. Pass/fail credit only, earned at the rate of one credit for every fifty hours of qualified work during an academic session. A maximum of four credits of BIOL 398 is allowed. Corequisite: COOP 098/099. Prerequisites: 45 total credits earned including BIOL 141 or 141H and 142 or 142H and 302, plus permission of the department. A description of the BIOL 398 requirements is available for download as a PDF [1-4]

BIOL 399 Tutorial Projects in Biological Sciences

Independent studies carried out with the supervision of a faculty member (maximum 6 credits). Note: This course is offered on a Pass/Fail basis only. Prerequisite: Consent of the supervising faculty member; upperclass standing. [1-3]

BIOL 405 Advanced Topics in Comparative Animal Physiology

This course takes a comparative approach to the study of how various selective pressures have resulted in the evolution of specific solutions to physiological problems. These solutions are viewed within the context of the fundamental limitations to biological evolution that are set by the physical and chemical properties of matter. The exact topic will change from semester to semester. Representative topics might include vision, temperature regulation and thermal tolerance, renal physiology, or cognitive neurophysiology. Most of the material covered will be from original research reports that will be evaluated critically by each student. Prerequisites: BIOL 305, PHYS 112, and MATH 151. [4]

BIOL 411 Bacterial Physiology

The combined approaches of bacterial genetics, molecular biology, and biochemistry are applied to the study of bacterial physiological processes. An emphasis is placed on examining adaptation strategies used by bacteria upon encountering alterations in environment. Topics include mechanisms of transcriptional and postranslational control, regulation of carbon and nitrogen metabolism, biosynthesis, energy transduction, signal transduction systems and bacterial development. Prerequisites: BIOL 302 and BIOL 303 or consent of instructor. BIOL 430 or CHEM 437 is recommended. [4]

BIOL 414 Eukaryotic Genetics and Molecular Biology

Genetics and molecular biology of lower and higher eukaryotes and their viruses. The course will focus on the maintenance and expression of genetic material as it relates to cell growth and development. It will cover current topics in the molecular genetics of several lower and higher eukaryotes at an advanced level, including mechanisms of genetic control which operate at the level of DNA replication, transcription and translation. Topics to include the molecular basis of phenomena such as gene amplification, global control of transcription initiation, protein sorting and secretion, control of yeast mating type as a model for development, the origin of antigen diversity, oncogenesis, pattern formation in Drosophila, sex determination in mammals. Prerequisites: BIOL 302 and BIOL 303, or consent of instructor. [4]

BIOL 418 Human Molecular Biology

The approaches of molecular biology and modern cell biology as applied to the study of both normal and diseased human states. Where appropriate, the analysis of other model mammalian experimental systems may be included. The course will involve the critical reading and discussion of the relevant research literature, and the preparation of one or more papers on specific issues or topics. The precise topics covered in any one semester will depend on the interest of the faculty and students, and with current developments in the field. Possible topics include: the molecular and cellular basis for human diseases, human molecular genetics, the human genome and proteomic project, human genetic therapy, and human evolution. Note: May be repeated for credit with a different topic. Prerequisites: BIOL 302 and 303 or permission of the instructor. [4]

BIOL 420 Advanced Topics in Cell Biology

Contemporary problems of structure and function at the cellular level through a critical examination of the current literature. The course includes both lecture material, with an emphasis on the experimental basis of current knowledge, and presentations by students of oral and written reports on selected topics. The area covered in any semester varies according to recent developments in the field and according to the interests of the students and faculty. The list of available areas includes: structure and function of biomembranes, composition, structure and replication of chromosomes; assembly, growth and reproduction of cytoplasmic organelles; cellular growth and division; regulation of cellular function; nuclear-cytoplasmic interactions; cytoskeletal structure and assembly. Prerequisite: BIOL 303. Note: May be repeated for credit with different topic. [4]

BIOL 422L Biological Electron Microscopy

Theory and practice of the study of biological materials with the high resolution of the electron microscope. Specimens will be prepared for examination by a variety of modern procedures. These include: tissue and cell fixation, embedding for ultrathin sectioning; carbon film preparation, mounting of particulate materials and macromolecules; positive and negative staining; metal shadowing in the vacuum evaporator; critical point drying. An introduction to scanning electron microscopy will be provided. The photographic darkroom procedures required for the production of finished electron micrographs are included. Prerequisites: BIOL 303 and/or permission of instructor. Note: This course will not meet the 400-level requirement for the major in Biological Sciences. Lab fee required. [4]

BIOL 425 Immunology

This course pursues in depth the rapidly expanding areas of cellular, humoral, and tumor immunology. Following a brief overview of the immune system’s response to exogenous antigen, the course concentrates on such topics as: antibody production and structure, lymphocyte sub-populations, cell-cell interactions, cell-mediated immune responses, cell surface alloantigens, histocompatibility immunogenetics, transplantation. and tumor immunology. The exact content of the course varies from year to year depending on the status of research in the field. Prerequisites: BIOL 302 and 303; BIOL 430 or CHEM 437 is recommended. [4]

BIOL 426 Approaches to Molecular Biology

This course will focus on the molecular biology of eukaryotic cells and will include such topics as the sequence organization of DNA and genes, chromosome structure, messenger RNA synthesis and processing, messenger RNA translation, and the regulation of the expression of genetic information. Prerequisites: BIOL 302, 303, or consent of the instructor. [4]

BIOL 428 Computer Applications in Molecular Biology

This course is designed as an introduction for biology and biochemistry students to the use of applications software in the analysis of DNA. RNA, and protein sequence data. Topics will include operating systems, telecommunications with off-campus databases, specific software packages for general and analytical treatment of DNA, RNA, and protein sequence data. Some elementary programming will be included. Pre requisites: BIOL 302 and BIOL 303.[4]

* BIOL 430 Biological Chemistry

An introductory course describing the essential principles of biochemistry. Topics include the structure and characterization of biological macromolecules, the energetics and thermodynamics of coupled biological reactions, and enzymology. The most important metabolic pathways are described, emphasizing their cellular compartmentalization, integration and control. Prerequisites: BIOL 303 and CHEM 352. [4]

* Class is offered at both the graduate and undergraduate level


BIOL 434 Microbial Molecular Genetics

Application of the combined approaches of microbial genetics, molecular biology, and biochemistry to the study of fundamental biological processes are demonstrated. The research literature is used to describe the current state of knowledge of the molecular mechanisms of microbial gene expression and the genetic biochemistry of chromosome structure, DNA replication, repair and recombination. Prerequisites: BIOL 302, 303 or consent of instructor. BIOL 430 or CHEM 437 is recommended. [4]  See a complete description of this course.

BIOL 442 Developmental Biology

A lecture course which considers the two major aspects of animal development: 1) the means by which, starting with a fertilized egg, progeny cells progressively differentiate from their precursors and one another to produce the ultimate diversity of the multicellular organism; and 2) the processes by which this increasingly complex population of cells is synthesized into a single integrated organism. Prerequisites: BIOL 302 and BIOL 303. [3]

BIOL 443 Advanced Topics in Developmental Biology

Designed to emphasize cellular, molecular and biochemical aspects of basic developmental questions, this course introduces the student to modern approaches to determination, differentiation and morphogenesis. Experimental design and analysis of data are emphasized. Possible topics include: molecular and cellular aspects of gametogenesis, fertilization, embryogenesis and continuous development in the adult; mechanisms of intra- and intercellular communication; pattern formation and positional information. Developmental model systems using unicellular organisms are considered. Prerequisite: BIOL 442. Note: May be repeated for credit with different topic. [4]

BIOL 444 Development and Cancer

This course will explore at the molecular level the interface between animal development and cancer. Through a combination of didactic lectures, reading of the primary scientific literature, and in-class presentations students will explore the latest advances in understanding how the processes that govern normal cell growth and differentiation become altered in cancer. Topics will include signaling mechanisms, stem cell biology, and cell cycle control. Prerequisite: BIOL 442. [4]

BIOL 445 Signal Transduction

This course will examine some of the methods by which the reception of signals from the environment leads to the changes in gene and protein activity in responding cells which constitute a biological response. Signal transduction in the context of developmental biology and neurobiology will be the main areas of study. Six to eight topics will be covered in detail. The design and interpretation of scientific experiments will be emphasized through critical reading, analysis and presentation of original articles from the primary literature. The use of genetic, molecular and biochemical techniques to address questions in the field of signal transduction will be examined. Prerequisites: BIOL 302 and 303. [4]

BIOL 451 Neurobiology

Nervous system function at the cellular level. Ionic mechanisms underlying electrical activity in nerve cells; the physiology of synapses; transduction and integration of sensory information; activity in populations of neurons: the specification of neuronal connections; and trophic and plastic properties of nerve cells. Prerequisite: BIOL 305 or consent of instructor. [4]

BIOL 453 Physiological Bases of Behavior

Studies of important adaptation behavioral patterns and their physiological bases. The course begins with some basic principles of the study of animal behavior followed by special topics such as sexual behavior, feeding, prey capture, and predator evasion, etc. Prerequisites: BIOL 305 or consent of instructor. [4]

BIOL 454 Vision Science

This course will focus in depth on visual systems of animals and humans. Coverage will span the range of modern research from the biochemistry and physiology of the photoreceptors to the ecology, evolution, and functional optimization of visual systems. Topics included: visual pigments, biochemical basis of phototransduction, visual processing and organization of visual centers of the brain, eyes, optical arrays, and visual evolution and ecology. Prerequisites: BIOL 305; BIOL 451 is recommended. [4]

BIOL 456 Plant Molecular Biology

Following a brief review of some important principles and techniques in molecular biology, this course pursues. in depth. such topics as the cloning and characterization of chloroplast, mitochondrial and nuclear genomes in plants; interactions of the nuclear and chloroplast gene products; genetic engineering of the nitrogen fixation genes, DNA plant viruses, and the Agrobacterium Ti plasmid. The course content reflects the status of research in this rapidly developing area. Prerequisite: BIOL 304. [4]

BIOL 457 Physiology of Marine and Estuarine Animals

A study of the physiological specializations demanded by marine/estuarine environments, including the following topics: Physiological mechanisms for coping with stresses imposed by extremes of temperature, salinity. aerial exposure, and low oxygen concentrations; sensory physiology including visual, chemical, and mechanical modalities; exogenous and endogenous rhythms related to tidal or diel cycles; and bioluminescence. The course includes one or more trips to field laboratories. Prerequisite: BIOL 305. [4]

BIOL 463 Theoretical and Quantitative Biology

A course in probability and advanced biostatistics. Topics will include the elementary mathematical techniques used in biology and medicine, the relationships among probability distributions used in standard statistical tests, univariate linear and non-linear analyses, correlation matrices and multivariate analyses, path analysis, cluster analysis, discriminant and principal component analyses. Students will present examples of the analyses from the literature. The class will solve problems and each student will analyze a set of experimental data. Prerequisites: STAT 350 and BIOL 301. [4]

BIOL 466 Population and Quantitative Genetics

The emphasis in this course is the study in natural populations of characters whose variation is controlled by multiple genes. The foundations in Mendelian and population genetics are described, followed by a comprehensive treatment of the field of quantitative genetics and then by a discussion of the place of quantitative genetics in behavioral genetics, physiological ecology, and in population biology in general. Prerequisites: STAT 350 and BIOL 301. [4]

BIOL 468 Ecology of Rivers and Streams

This course provides an understanding of the structure and functions of lotic ecosystems and how these systems operate in terms of energetics, interactions among component species, and the physical and chemical properties of undisturbed and disturbed watersheds. Special attention will be given to the relationships between biodiversity, species substitutability and ecosystem processing as they relate to the conservation and protection of rivers, streams and non-tidal wetlands. Prerequisite: BIOL 301, CHEM 102 and junior standing. [4]

BIOL 476 Antibotics: Origin, Mechanism, Resistance

Infectious agents, the bacteria and viruses, accounted for 57% of the deaths in the US in 1900 and less than 4% in 1990. The discovery and application of antibiotics and other chemotherapeutic agents are largely responsible for this dramatic reversal. In this course, the origin of selected chemotherapeutic agents, their detailed mode of action and the basis for emergence of resistant microbial populations will be discussed. Similarly, the action of selected drugs used in chemotherapy which attempts to control cancer cell growth will be outlined. The principle of “rational drug design” and radical “new” methods of attacking microbial populations will be explored. Prerequisite: BIOL 302, BIOL 303, CHEM 351. [4]

BIOL 477 Applications of Biodetection Approaches

The ability to detect and identify genetic and protein markers forms a common theme for many different fields of biological sciences including medical diagnostics, environmental microbiology, food/water safety, biodefense/homeland security, and veterinary science. Because of its central role throughout a diverse set of biological disciplines the methods and approaches for biodetection are extremely varied and wide-ranging. This course begins with basic detection approaches and continues with examples of principles guiding biodetection by relating each approach to important present-day challenges facing society. The course will also include an in-depth analysis of biological principles guiding detection strategies to understand not only the potential but also the limitations of each approach. Prerequisite: BIOL 302 and BIOL 303 with a grade of C or better. [4]

BIOL 483 Evolution: From Genes to Genomes

This is a combined lecture and hands-on computing course comprising four major sections that study the applications of evolutionary theory to the exploration and analysis of phenotypic and biological sequence data. We will begin by building a sound conceptual basis for the theory of evolution, including an introduction to population genetics. Real biological sequence data then will be introduced and used to illustrate and extend this theory. From here, the focus will shift to some major branches of current evolutionary research, introducing recent published work for each topic. Finally, we will stage a series of student-led debates that require application of the science that has been learned to current socio-political areas of controversy. Prerequisite: BIOL 301 and 302. [4]

BIOL 486 Genome Science

Life science at the whole genome level represents a rapidly expanding new paradigm that defines a new field, genome science. BIOL486 provides students with the requisites for understanding genome science and includes experimental basics of functional genomics and analytical basics of bioinformatics. Biomedical and agricultural research are developing the potential of genome science, in both the public and private sectors. Important questions that have been unapproachable are now thought to be within reach. For example, students in BIOL 486 will learn how genome science may provide tools to unravel the arcane genetics of complex diseases and traits. Information sources will include textbook(s), the primary literature, and computer methods. [4]

BIOL 495 Seminar in Bioinformatics

A “capstone” seminar course for students in the Bioinformatics and Computational Biology Program. Students will be introduced to examples of the integrated uses of the various disciplines that together comprise bioinformatics and computational biology. Prerequisites: Permission of Instructor; junior standing. [2-4]

BIOL 497H Honors Thesis

Students who are pursuing departmental honors will write and submit a scholarly paper reporting on the outcome of their senior research project. Prerequisite: Approval of the Departmental Honors Program advisor. [2]

BIOL 499 Undergraduate Laboratory/Field Research

Original laboratory or field research appropriate to upperclass students, conducted under the supervision of a faculty member. This course does not fulfill the 400-level course requirement for the major in the Biological Sciences. Note: This course is offered on P/F basis only. Prerequisites: Consent of the supervising faculty member; upperclass standing. [1-4]

BIOL 499H Undergraduate Laboratory/Field Research

Original laboratory or field research for students in the Biological Sciences Honors Program to be conducted under the supervision of a faculty member. Note: This course does not fulfill the 400-level course requirement for the major in biological sciences. This course of fered on a P/F basis only. Prerequisite: Acceptance in the Biological Sciences Honors Program and permission of the supervising faculty member. [1-6]