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Rachel Brewster

Assoc Prof

Biological Sciences
brewster@umbc.edu
Education
Ph D, University of Michigan (1996)
Website
About

Received a BS degree from the University of Geneva in 1989, Switzerland and a PhD from the University of Michigan, Ann Arbor, MI (1996). Postdoctoral work in the area of developmental neurobiology in the laboratories of Dr Ariel Ruiz i Altaba at NYU, Skirball Institute of Biomedical Sciences, NY, NY (1996-1999) and Dr Marnie Halpern at the Carnegie Institution for Science, Dept of Embryology, Baltimore (MD) (2000-2003).

Research Interests

Regulation of brain development and metabolism.

Teaching Interests

Developmental biology, cell biology, metabolism, genetics.

Selected Classes
Fall 2019 BIOL 442 – Developmental Biology
BIOL 642 – Intro To Dev Biology
Fall 2014 BIOL 442 – Developmental Biology
Contracts, Fellowships, Grants, and Sponsored Research

Brewster, Rachel M. Three-Dimensional Printing of Micro-Capillary Needle via Direct Laser Writing Grant Sponsored by NSF (Mar 1, 2020 – Feb 2, 2021)

Brewster, Rachel M. (Co-Principal) Rand, Kinneret (Principal) THE MICROINJECTION COLORED NEEDLE FOR ENHANCED VISIBILITY AND ANTI-CLOGGING CAPABILITIES Grant (Funded) Sponsored by NIH/NIGMS (Mar 1, 2019 – Aug 31, 2020)

Brewster, Rachel M. (Co-Principal) Rand, Kinneret (Principal) Rosenzweig, Zeev (Co-Principal) The Microinjection Colored Needle For Enhanced Visibility and Anti-Clogging Capabilities Grant (Funded) Sponsored by UMBC (Mar 1, 2019 – Aug 31, 2019)

Brewster, Rachel M. (Principal) Lee, Young-Sam (Co-Principal) Signaling mechanisms that mediate anoxia-induced cellular arrest Grant (Funded) Sponsored by NIH/NICHD (Aug 16, 2018 – Aug 15, 2020)

Brewster, Rachel M. (Principal) Lee, Young-Sam (Co-Principal) Novel inducers of hypometabolism for preservation of transplant tissue Grant (Funded) Sponsored by Department of Defense (Sep 30, 2016 – Sep 29, 2019)

Brewster, Rachel M. (Principal) Hypoxia-induced melatonin synthesis as a mechanism to promote hypometabolism Grant (Not Funded) Sponsored by Brain Research Foundation

Brewster, Rachel M. (Principal) NDRG1 as a molecular switch for removal of proto-oncogenes from the plasma membrane Grant (Not Funded) Sponsored by Department of Defense

Brewster, Rachel M. (Principal) Zebrafish as a screening model for neural tube defect predisposition factors Grant (Not Funded) Sponsored by NIH/NICHD

Intellectual Contributions

38 vol. 39 7465-7484 Journal of Neuroscience

Hypoxia-induced regulation of NDRG expression in the developing zebrafish embryo

Finally sinking in: conserved mechanisms of forebrain neurulation TBD

39(38) 7465-7484.

Anoxia-induced developmental arrest is mediated by members of the N-myc Downstream Regulated (NDRG) gene family

Baltimore Communications Biology

Presentations

(Author & Presenter) (Author) (Author) ABRCMS Poster Effects of NDRG1 Expression on Na+/K+-ATPase Localization Anaheim, CA

(Author & Presenter) (Author) (Author) ABRCMS Poster The effect of hyperglycemia on neurulation Annaheim, CA

(Author & Presenter) (Author) (Author) (Author) 11th International Neural Tube Defects Conference Poster Establishing zebrafish as a model to study genetic components underlying neural tube defects using conservation of cellular and genetic components Harvard Medical School

(Author & Presenter) (Author) (Author) 11th International Neural Tube Defects Meeting Poster Apical constriction molecular machinary in the zebrafish medial hingepoint Harvard Medical School

(Author & Presenter) (Author) (Author) 11th International Neural Tube Defects Meeting Oral Presentation Hallmarks of primary neurulation observed in zebrafish: implication for screening genetic variants implicated in cranial neural tube defects Harvard Medical School

(Author & Presenter) (Author) (Author) Society for Developmental Biology 78th Annual Meeting Poster Forebrain morphogenesis in zebrafish presents previously overlooked hallmarks of primary neurulation Harvard Medical School

(Author & Presenter) (Author) (Author) Society for Developmental Biology 78th Annual Meeting Poster Unraveling Transcriptional Regulation Imparted by N-Myc Downstream Regulated Gene 1a (NDRG1a) Under Anoxia in Zebrafish Boston, MA

(Author & Presenter) (Author) (Author) Summer Undergraduate Research Festival Poster Effect of hyperglycemia on neurulation UMBC

(Author & Presenter) (Author) (Author) (Author) Summer Undergraduate Research Festival Poster Evidence for Conserved Mechanisms of Neurulation in the Zebrafish Forebrain UMBC

(Author & Presenter) (Author) (Author) Summer Undergraduate Research Festival Poster Is the downregulation of Na-K-ATPase due to clathryn-mediated endocytosis under hypoxia? UMBC

(Author & Presenter) (Author) (Author) Summer Undergraduate Research Festival Poster NDRG1 protects the kidney from hypoxic damage UMBC

(Author & Presenter) (Author) (Author) Summer Undergraduate Research Festival Poster Role of NDRG3 in Cellular Arrest Under Anoxia UMBC

(Author & Presenter) (Author) (Author) Summer Undergraduate Research Festival Oral Presentation Role of the N-Myc Downstream Regulated Gene (NDRG) 1 in the Adaptation of the Kidney to Low Oxygen UMBC

(Author) (Author) (Author) Summer Undergraduate Research Festival Poster The effect of hyperglycemia on neurulation UMBC

(Author & Presenter) (Author) Mid-Atlantic Regional Meeting of the Society for Developmental Biology Poster Cellular analysis of forebrain morphogenesis in zebrafish shows conservation of mechanisms in vertebrates SDB Penn State University

(Author & Presenter) (Author) Mid-Atlantic Regional Meeting of the Society for Developmental Biology Poster Role of N-Myc Downstream Regulated Gene family in low oxygen adaptation SDB Penn State University

(Author & Presenter) (Author) (Author) URCAD Poster Role of N-myc Downsteam Regulated Gene 1 (NDRG1) in cellular arrest under anoxia UMBC

(Author & Presenter) (Author) (Author) URCAD Oral Presentation Role of N-myc Dowstream Regulated Gene (NDRG1) in the adaptation of the kidney to low oxygen UMBC

(Author & Presenter) (Author) (Author) (Author) URCAD Poster The Role of Lactate as a Stabilizing Molecule for NDRG1-Mediated Energy UMBC

(Author & Presenter) (Author) Mid-Atantoc Regional Zebrafish Meeting Poster Role of the N-Myc Downstream Regulated Gene (NDRG) 1 in the Adaptation of the Kidney to Low Oxygen (Oral Presentation) University of Maryland

(Author & Presenter) (Author) Mid-Atlantic Regional Zebrafish Meeting Poster Role of N-myc Downsteam Regulated Gene 1 (NDRG1) in cellular arrest under anoxia University of Maryland

(Author & Presenter) (Author) Mid-Atlantic Regional Zebrafish Meeting Poster Role of N-myc Downsteam Regulated Gene 1 (NDRG1) in cellular arrest under anoxia University of Maryland

(Author) (Author) Mid-Atlantic Regional Zebrafish Meeting Oral Presentation Role of N-myc Downsteam Regulated Gene 1 (NDRG1) in cellular arrest under anoxia University of Maryland

(Author & Presenter) (Author) Mid-Atlantic Regional Zebrafish Meeting Poster Role of N-Myc Downstream Regulated Gene family in low oxygen adaptation University of Maryland

(Author & Presenter) (Author) (Author) Mid-Atlantic Regional Zebrafish Meeting Poster Role of N-Myc Downstream Regulated Gene family in low oxygen adaptation University of Maryland

(Author & Presenter) (Author) Mid-Atlantic Regional Zebrafish Meeting Poster Unraveling Transcriptional Regulation Imparted by N-Myc Downstream Regulated Gene 1a (NDRG1a) Under Anoxia in Zebrafish University of Maryland

(Author & Presenter) (Author) (Author) (Author) (Author) (Author) (Author) (Author) (Author) International Hypoxia Symposia Oral Presentation Lactate-NDRG1 signaling mediates low oxygen adaptation in the kidney Alberta, Canada

(Author & Presenter) (Author) International Hypoxia Symposia Poster Role of N-myc Downsteam Regulated Gene 1 (NDRG1) in cellular arrest under anoxia Alberta, Canada

(Author & Presenter) (Author) International Hypoxia Symposia Poster Role of N-myc Downstream Regulated Gene 1 in adaptation of the kidney to low oxygen Alberta, Canada

(Author & Presenter) (Author) International Hypoxia Symposia Oral Presentation Role of NDRG1 signaling in adaptation to low oxygen tolerance Alberta, Canada

(Author & Presenter) (Author) International Hypoxia Symposia Oral Presentation Role of the N-Myc Downstream Regulated Gene (NDRG) 1 in the Adaptation of the Kidney to Low Oxygen Alberta, Canada

(Author & Presenter) International Hypoxia Symposia Poster Unraveling Transcriptional Regulation Imparted by N-Myc Downstream Regulated Gene 1a (NDRG1a) Under Anoxia in Zebrafish Alberta, Canada

(Author & Presenter) (Author) (Author) (Author) (Author) (Author) (Author) (Author) (Author) Strategic Conference of Zebrafish Investigators Oral Presentation Lactate-NDRG1 signaling mediates low oxygen adaptation in the kidney Asilomar, CA

(Author & Presenter) (Author) 2nd Annual USM LSAMP Fall Research Symposium Poster Apical constriction machinery within the zebrafish medial hingepoint UMB

(Author & Presenter) (Author) The American Society for Cell Biology Poster Vangl2 regulates key cellular events driving anterior neural tube morphogenesis San Diego, CA

(Author & Presenter) (Author) Mid-Atlantic Regional Zebrafish Meeting Poster Role of N-Myc Downstream Regulated Gene Family in Low Oxygen Adaptation U Penn

(Author & Presenter) (Author) Annual Biomedical Research Conference for Minority Students (ABRCMS) Poster Apical constriction machinery within the zebrafish medial hingepoint Indianapolis, Indiana

(Author & Presenter) (Author) Annual Biomedical Research Conference for Minority Students (ABRCMS) Poster Role of N-Myc Downstream Regulated Gene Family in Low Oxygen Adaptation Indianapolis, Indiana

(Author & Presenter) (Author) Annual Biomedical Research Conference for Minority Students (ABRCMS) Poster Providing cellular and molecular evidence for the presence of hingepoints within the zebrafish forebrain Indianapolis, Indiana

(Author & Presenter) (Author) Annual Biomedical Research Conference for Minority Students (ABRCMS) Poster Role of N-Myc Downstream Regulated Gene 1 (NDRG1) in cellular arrest under anoxia Indianapolis, Indiana

(Author & Presenter) (Author) Undergraduate Research and Creative Achievement Day (URCAD) Poster Providing cellular and molecular evidence for the presence of hingepoints within the zebrafish forebrain UMBC UMBC

(Author & Presenter) (Author) Undergraduate Research and Creative Achievement Day (URCAD) Poster The Role of Protein Synthesis in Cellular Arrest and Organismal Survival Under Anoxia UMBC UMBC

(Author & Presenter) (Author) Undergraduate Research and Creative Achievement Day (URCAD) Poster Van-Gogh-like 2, Frizzled, Knypek and N-Cadherin control distinct aspects of polarized cellular migration during neural convergence

(Author & Presenter) (Author) Summer Undergraduate Research Fest (SURF) Poster Apical constriction molecular machinery within the zebrafish hingepoint UMBC UMBC

(Author) (Author & Presenter) Summer Undergraduate Research Fest (SURF) Poster Localization of NDRG1A under hypoxia condition using Immunohistochemistry (IHC) UMBC UMBC

(Author & Presenter) (Author) Summer Undergraduate Research Fest (SURF) Poster Role of N-Myc Downstream Regulated Gene Family in Low Oxygen Adaptation UMBC UMB

(Author & Presenter) (Author) Summer Undergraduate Research Fest (SURF) Poster The Role of Lactate as a Stabilizing Molecule for NDRG1-Mediated Energy Preservation Under Anoxia UMBC UMBC

(Author & Presenter) (Author) 77th Annual Meeting of the Society for Developmental Biology Poster Conserved and novel role for the Planar Cell Polarity component Vangl2 in shaping the zebrafish anterior neural tube. Poster. Portland, Oregon

(Author & Presenter) (Author) 77th Annual Meeting of the Society for Developmental Biology Poster Investigating the relationship between cell cycle arrest and development in anoxia-tolerant zebrafish Portland, Oregon

(Author & Presenter) UMBC - Meyerhoff (undergrad) Oral Presentation Survival in absence of oxygen: insights from the zebrafish embryo UMBC UMBC

(Author & Presenter) (Author) Mid-Atlantic Meeting of the Society of Developmental Biology (SDB) Poster Conserved and novel role for the Planar Cell Polarity component Vangl2 in shaping the zebrafish anterior neural tube U Virginia Charlottesville, VA

(Author & Presenter) (Author) Mid-Atlantic Meeting of the Society of Developmental Biology (SDB) Poster Role of N-Myc Downstream Regulated Gene Family in Low Oxygen Adaptation U Virginia Charlottesville, VA

(Author & Presenter) (Author) Undergraduate Research and Creative Achievement Day (URCAD) Poster Role of N-Myc Downstream Regulated Gene Family in Low Oxygen Adaptation UMBC UMBC

(Author & Presenter) (Author) Undergraduate Research and Creative Achievement Day (URCAD) Poster The Role of Lactate as a Stabilizing Molecule for NDRG1-Mediated Energy Preservation Under Anoxia UMBC UMBC

(Author & Presenter) Seminar Life without oxygen: insights from the zebrafish embryo Uniformed Serviices University

(Author & Presenter) (Author) (Author) (Author) (Author) Keystone Meeting on Adaptations to Hypoxia in Physiology and Disease Poster Signaling mechanisms that mediate anoxia-induced physiological arrest in the zebrafish embryo Oxford U, Oxford, UK

(Author & Presenter) (Author) Keystone Symposium on Therapeutic Targeting of Hypoxia Sensitive Pathways Oral Presentation Lactate-NDRG1 signaling mediates low oxygen adaptation in the kidney U of Oxford, Oxford, UK

(Author & Presenter) (Author) Graduate Research Conference Oral Presentation From a brain birth defect to underlying genetics UMBC UMBC

(Author & Presenter) Invited talk Seminar Cellular mechanisms underlying brain morphogenesis U of Wisconsin-Madison

(Author & Presenter) (Author) Graduate Association of Biological Sciences Symposium Oral Presentation Role of NDRG1 signaling in adaptation to low oxygen tolerance UMBC UMBC

(Author & Presenter) (Author) PROMISE AGEP Research Symposium & Professional Development Conference Oral Presentation From a brain birth defect to underlying genetics UM system UMCP

(Author & Presenter) (Author) International Conference on Neural Tube Defects Oral Presentation Cellular mechanisms underlying forebrain morphogenesis Austin, Texas

International Conference on Neural Tube Defects Poster The Planar Cell Polarity pathway promotes polarized migration and intercalation that drive neural tube morphogenesis in the zebrafish embryo Austin, Texas

(Author) (Author & Presenter) International Conference on Neural Tube Defects Poster The Role of the Neogenin Intracellular Domain (Neo-ICD) in Neurulation Austin, Texas

(Author) (Author & Presenter) Keystone Meeting on Adaptations to Hypoxia in Physiology and Disease Oral Presentation Role of NDRG1 signaling in tissue specific anoxia tolerance Whistler Conference Centre

(Author & Presenter) 7th Strategic Conference of Zebrafish Investigators (SCZI) Poster Understanding the Induction of Suspended Animation in Zebrafish Asilomar, CA

(Presenter) Allied Genetics Conference Oral Presentation Role of RGMa/Neo signaling in Brain Development GSA Orlando, FL

(Presenter) Mid-Atlantic Zebrafish Meeting Oral Presentation Role of RGMa/Neo signaling in Brain Development U Penn

(Author & Presenter) SACNAS Oral Presentation The brawn behind brain cells: microtubules and their regulators Society for Advancement of Chicanos and Native Americans in Science Washington DC