Rachel Brewster
Assoc Prof
| brewster@umbc.edu | |
| Education |
Ph D, University of Michigan (1996)
|
| Website | http://umbc.edu/biosci/general/user/brewster |
About
Received a BS degree from the University of Geneva in 1989, Switzerland and a PhD from the University of Michigan, Ann Arbor, MI (1996). Postdoctoral work in the area of developmental neurobiology in the laboratories of Dr Ariel Ruiz i Altaba at NYU, Skirball Institute of Biomedical Sciences, NY, NY (1996-1999) and Dr Marnie Halpern at the Carnegie Institution for Science, Dept of Embryology, Baltimore (MD) (2000-2003).
Research Interests
Regulation of brain development and metabolism.
Teaching Interests
Developmental biology, cell biology, metabolism, genetics.
Selected Classes
| Fall 2019 | BIOL 442 – Developmental Biology |
|---|---|
| BIOL 642 – Intro To Dev Biology | |
| Fall 2014 | BIOL 442 – Developmental Biology |
Contracts, Fellowships, Grants, and Sponsored Research
Three-Dimensional Printing of Micro-Capillary Needle via Direct Laser Writing Grant Sponsored by NSF (Mar 1, 2020 – Feb 2, 2021)
THE MICROINJECTION COLORED NEEDLE FOR ENHANCED VISIBILITY AND ANTI-CLOGGING CAPABILITIES Grant (Funded) Sponsored by NIH/NIGMS (Mar 1, 2019 – Aug 31, 2020)
The Microinjection Colored Needle For Enhanced Visibility and Anti-Clogging Capabilities Grant (Funded) Sponsored by UMBC (Mar 1, 2019 – Aug 31, 2019)
Signaling mechanisms that mediate anoxia-induced cellular arrest Grant (Funded) Sponsored by NIH/NICHD (Aug 16, 2018 – Aug 15, 2020)
Novel inducers of hypometabolism for preservation of transplant tissue Grant (Funded) Sponsored by Department of Defense (Sep 30, 2016 – Sep 29, 2019)
Hypoxia-induced melatonin synthesis as a mechanism to promote hypometabolism Grant (Not Funded) Sponsored by Brain Research Foundation
NDRG1 as a molecular switch for removal of proto-oncogenes from the plasma membrane Grant (Not Funded) Sponsored by Department of Defense
Zebrafish as a screening model for neural tube defect predisposition factors Grant (Not Funded) Sponsored by NIH/NICHD
Intellectual Contributions
(2019) Rgma-induced Neo1 proteolysis promotes neural tube morphogenesis Journal of Neuroscience
Hypoxia-induced regulation of NDRG expression in the developing zebrafish embryo
Finally sinking in: conserved mechanisms of forebrain neurulation TBD
Anoxia-induced developmental arrest is mediated by members of the N-myc Downstream Regulated (NDRG) gene family
Cellular analysis of forebrain morphogenesis in the zebrafish embryo reveals conserved features of primary neurulation Baltimore Communications Biology
Presentations
ABRCMS Poster Effects of NDRG1 Expression on Na+/K+-ATPase Localization Anaheim, CA (Nov 13, 2019)
ABRCMS Poster The effect of hyperglycemia on neurulation Annaheim, CA (Nov 13, 2019)
11th International Neural Tube Defects Conference Poster Establishing zebrafish as a model to study genetic components underlying neural tube defects using conservation of cellular and genetic components Harvard Medical School (Sep 16, 2019)
11th International Neural Tube Defects Meeting Poster Apical constriction molecular machinary in the zebrafish medial hingepoint Harvard Medical School (Sep 16, 2019)
11th International Neural Tube Defects Meeting Oral Presentation Hallmarks of primary neurulation observed in zebrafish: implication for screening genetic variants implicated in cranial neural tube defects Harvard Medical School (Sep 16, 2019)
Society for Developmental Biology 78th Annual Meeting Poster Forebrain morphogenesis in zebrafish presents previously overlooked hallmarks of primary neurulation Harvard Medical School (Jul 26, 2019)
Society for Developmental Biology 78th Annual Meeting Poster Unraveling Transcriptional Regulation Imparted by N-Myc Downstream Regulated Gene 1a (NDRG1a) Under Anoxia in Zebrafish Boston, MA (Jul 26, 2019)
Summer Undergraduate Research Festival Poster Effect of hyperglycemia on neurulation UMBC (Jul 24, 2019)
Summer Undergraduate Research Festival Poster Evidence for Conserved Mechanisms of Neurulation in the Zebrafish Forebrain UMBC (Jul 24, 2019)
Summer Undergraduate Research Festival Poster Is the downregulation of Na-K-ATPase due to clathryn-mediated endocytosis under hypoxia? UMBC (Jul 24, 2019)
Summer Undergraduate Research Festival Poster NDRG1 protects the kidney from hypoxic damage UMBC (Jul 24, 2019)
Summer Undergraduate Research Festival Poster Role of NDRG3 in Cellular Arrest Under Anoxia UMBC (Jul 24, 2019)
Summer Undergraduate Research Festival Oral Presentation Role of the N-Myc Downstream Regulated Gene (NDRG) 1 in the Adaptation of the Kidney to Low Oxygen UMBC (Jul 24, 2019)
Summer Undergraduate Research Festival Poster The effect of hyperglycemia on neurulation UMBC (Jul 24, 2019)
Mid-Atlantic Regional Meeting of the Society for Developmental Biology Poster Cellular analysis of forebrain morphogenesis in zebrafish shows conservation of mechanisms in vertebrates SDB Penn State University (May 17, 2019)
Mid-Atlantic Regional Meeting of the Society for Developmental Biology Poster Role of N-Myc Downstream Regulated Gene family in low oxygen adaptation SDB Penn State University (May 17, 2019)
URCAD Poster Role of N-myc Downsteam Regulated Gene 1 (NDRG1) in cellular arrest under anoxia UMBC (Apr 24, 2019)
URCAD Oral Presentation Role of N-myc Dowstream Regulated Gene (NDRG1) in the adaptation of the kidney to low oxygen UMBC (Apr 24, 2019)
URCAD Poster The Role of Lactate as a Stabilizing Molecule for NDRG1-Mediated Energy UMBC (Apr 24, 2019)
Mid-Atantoc Regional Zebrafish Meeting Poster Role of the N-Myc Downstream Regulated Gene (NDRG) 1 in the Adaptation of the Kidney to Low Oxygen (Oral Presentation) University of Maryland (Apr 5, 2019)
Mid-Atlantic Regional Zebrafish Meeting Poster Role of N-myc Downsteam Regulated Gene 1 (NDRG1) in cellular arrest under anoxia University of Maryland (Apr 5, 2019)
Mid-Atlantic Regional Zebrafish Meeting Poster Role of N-myc Downsteam Regulated Gene 1 (NDRG1) in cellular arrest under anoxia University of Maryland (Apr 5, 2019)
Mid-Atlantic Regional Zebrafish Meeting Oral Presentation Role of N-myc Downsteam Regulated Gene 1 (NDRG1) in cellular arrest under anoxia University of Maryland (Apr 5, 2019)
Mid-Atlantic Regional Zebrafish Meeting Poster Role of N-Myc Downstream Regulated Gene family in low oxygen adaptation University of Maryland (Apr 5, 2019)
Mid-Atlantic Regional Zebrafish Meeting Poster Role of N-Myc Downstream Regulated Gene family in low oxygen adaptation University of Maryland (Apr 5, 2019)
Mid-Atlantic Regional Zebrafish Meeting Poster Unraveling Transcriptional Regulation Imparted by N-Myc Downstream Regulated Gene 1a (NDRG1a) Under Anoxia in Zebrafish University of Maryland (Apr 5, 2019)
International Hypoxia Symposia Oral Presentation Lactate-NDRG1 signaling mediates low oxygen adaptation in the kidney Alberta, Canada (Feb 19, 2019)
International Hypoxia Symposia Poster Role of N-myc Downsteam Regulated Gene 1 (NDRG1) in cellular arrest under anoxia Alberta, Canada (Feb 19, 2019)
International Hypoxia Symposia Poster Role of N-myc Downstream Regulated Gene 1 in adaptation of the kidney to low oxygen Alberta, Canada (Feb 19, 2019)
International Hypoxia Symposia Oral Presentation Role of NDRG1 signaling in adaptation to low oxygen tolerance Alberta, Canada (Feb 19, 2019)
International Hypoxia Symposia Oral Presentation Role of the N-Myc Downstream Regulated Gene (NDRG) 1 in the Adaptation of the Kidney to Low Oxygen Alberta, Canada (Feb 19, 2019)
International Hypoxia Symposia Poster Unraveling Transcriptional Regulation Imparted by N-Myc Downstream Regulated Gene 1a (NDRG1a) Under Anoxia in Zebrafish Alberta, Canada (Feb 19, 2019)
Strategic Conference of Zebrafish Investigators Oral Presentation Lactate-NDRG1 signaling mediates low oxygen adaptation in the kidney Asilomar, CA (Jan 12, 2019)
2nd Annual USM LSAMP Fall Research Symposium Poster Apical constriction machinery within the zebrafish medial hingepoint UMB (Dec 8, 2018)
The American Society for Cell Biology Poster Vangl2 regulates key cellular events driving anterior neural tube morphogenesis San Diego, CA (Dec 8, 2018)
Mid-Atlantic Regional Zebrafish Meeting Poster Role of N-Myc Downstream Regulated Gene Family in Low Oxygen Adaptation U Penn (Dec 7, 2018)
Annual Biomedical Research Conference for Minority Students (ABRCMS) Poster Apical constriction machinery within the zebrafish medial hingepoint Indianapolis, Indiana (Nov 14, 2018)
Annual Biomedical Research Conference for Minority Students (ABRCMS) Poster Role of N-Myc Downstream Regulated Gene Family in Low Oxygen Adaptation Indianapolis, Indiana (Nov 14, 2018)
Annual Biomedical Research Conference for Minority Students (ABRCMS) Poster Providing cellular and molecular evidence for the presence of hingepoints within the zebrafish forebrain Indianapolis, Indiana (Nov 13, 2018)
Annual Biomedical Research Conference for Minority Students (ABRCMS) Poster Role of N-Myc Downstream Regulated Gene 1 (NDRG1) in cellular arrest under anoxia Indianapolis, Indiana (Oct 20, 2018)
Undergraduate Research and Creative Achievement Day (URCAD) Poster Providing cellular and molecular evidence for the presence of hingepoints within the zebrafish forebrain UMBC UMBC (Oct 20, 2018)
Undergraduate Research and Creative Achievement Day (URCAD) Poster The Role of Protein Synthesis in Cellular Arrest and Organismal Survival Under Anoxia UMBC UMBC (Oct 20, 2018)
Undergraduate Research and Creative Achievement Day (URCAD) Poster Van-Gogh-like 2, Frizzled, Knypek and N-Cadherin control distinct aspects of polarized cellular migration during neural convergence (Oct 20, 2018)
Summer Undergraduate Research Fest (SURF) Poster Apical constriction molecular machinery within the zebrafish hingepoint UMBC UMBC (Aug 8, 2018)
Summer Undergraduate Research Fest (SURF) Poster Localization of NDRG1A under hypoxia condition using Immunohistochemistry (IHC) UMBC UMBC (Aug 8, 2018)
Summer Undergraduate Research Fest (SURF) Poster Role of N-Myc Downstream Regulated Gene Family in Low Oxygen Adaptation UMBC UMB (Aug 8, 2018)
Summer Undergraduate Research Fest (SURF) Poster The Role of Lactate as a Stabilizing Molecule for NDRG1-Mediated Energy Preservation Under Anoxia UMBC UMBC (Aug 8, 2018)
77th Annual Meeting of the Society for Developmental Biology Poster Conserved and novel role for the Planar Cell Polarity component Vangl2 in shaping the zebrafish anterior neural tube. Poster. Portland, Oregon (Jul 20, 2018)
77th Annual Meeting of the Society for Developmental Biology Poster Investigating the relationship between cell cycle arrest and development in anoxia-tolerant zebrafish Portland, Oregon (Jul 20, 2018)
UMBC - Meyerhoff (undergrad) Oral Presentation Survival in absence of oxygen: insights from the zebrafish embryo UMBC UMBC (Jun 15, 2018)
Mid-Atlantic Meeting of the Society of Developmental Biology (SDB) Poster Conserved and novel role for the Planar Cell Polarity component Vangl2 in shaping the zebrafish anterior neural tube U Virginia Charlottesville, VA (May 30, 2018)
Mid-Atlantic Meeting of the Society of Developmental Biology (SDB) Poster Role of N-Myc Downstream Regulated Gene Family in Low Oxygen Adaptation U Virginia Charlottesville, VA (May 30, 2018)
Undergraduate Research and Creative Achievement Day (URCAD) Poster Role of N-Myc Downstream Regulated Gene Family in Low Oxygen Adaptation UMBC UMBC (Apr 25, 2018)
Undergraduate Research and Creative Achievement Day (URCAD) Poster The Role of Lactate as a Stabilizing Molecule for NDRG1-Mediated Energy Preservation Under Anoxia UMBC UMBC (Apr 25, 2018)
Seminar Life without oxygen: insights from the zebrafish embryo Uniformed Serviices University (Apr 24, 2018)
Keystone Meeting on Adaptations to Hypoxia in Physiology and Disease Poster Signaling mechanisms that mediate anoxia-induced physiological arrest in the zebrafish embryo Oxford U, Oxford, UK (Apr 10, 2018)
Keystone Symposium on Therapeutic Targeting of Hypoxia Sensitive Pathways Oral Presentation Lactate-NDRG1 signaling mediates low oxygen adaptation in the kidney U of Oxford, Oxford, UK (Apr 10, 2018)
Graduate Research Conference Oral Presentation From a brain birth defect to underlying genetics UMBC UMBC (Mar 28, 2018)
Invited talk Seminar Cellular mechanisms underlying brain morphogenesis U of Wisconsin-Madison (Mar 9, 2018)
Graduate Association of Biological Sciences Symposium Oral Presentation Role of NDRG1 signaling in adaptation to low oxygen tolerance UMBC UMBC (Mar 8, 2018)
PROMISE AGEP Research Symposium & Professional Development Conference Oral Presentation From a brain birth defect to underlying genetics UM system UMCP (Feb 16, 2018)
International Conference on Neural Tube Defects Oral Presentation Cellular mechanisms underlying forebrain morphogenesis Austin, Texas (Oct 1, 2017)
International Conference on Neural Tube Defects Poster The Planar Cell Polarity pathway promotes polarized migration and intercalation that drive neural tube morphogenesis in the zebrafish embryo Austin, Texas (Oct 1, 2017)
International Conference on Neural Tube Defects Poster The Role of the Neogenin Intracellular Domain (Neo-ICD) in Neurulation Austin, Texas (Oct 1, 2017)
Keystone Meeting on Adaptations to Hypoxia in Physiology and Disease Oral Presentation Role of NDRG1 signaling in tissue specific anoxia tolerance Whistler Conference Centre (Mar 5, 2017)
7th Strategic Conference of Zebrafish Investigators (SCZI) Poster Understanding the Induction of Suspended Animation in Zebrafish Asilomar, CA (Jan 16, 2017)
Allied Genetics Conference Oral Presentation Role of RGMa/Neo signaling in Brain Development GSA Orlando, FL (Jul 16, 2016)
Mid-Atlantic Zebrafish Meeting Oral Presentation Role of RGMa/Neo signaling in Brain Development U Penn (Apr 29, 2016)
SACNAS Oral Presentation The brawn behind brain cells: microtubules and their regulators Society for Advancement of Chicanos and Native Americans in Science Washington DC (Oct 29, 2015)