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Daniel Lobo

Daniel Lobo

Associate Professor

Biological Sciences

Biological Sciences 115

Education

Postdoc Tufts University 2015

Ph D University of Malaga 2010

MS University of Malaga 2007

BS University of Seville 2005

Research Interests

The Lobo Lab aims to understand the regulation and mechanisms of biological growth, shape, and pattern formation with a systems biology approach. We combine both molecular and computational methods to gain a mechanistic understanding of development and regeneration, find personalized treatments for cancer, and streamline regulatory designs in synthetic biology. We have developed new techniques for the acquisition and formalization of microscopy spatial data, the formulation of mechanistic models of genetic, metabolic, and signaling networks, and high-performance machine learning methods for inferring such models. We combine these computational methods with molecular assays at the bench for obtaining quantitative spatial and dynamic data, such as gene expression and morphological outcomes, and for prediction validation including genetic, surgical, and pharmacological perturbations and the engineering of synthetic circuits. This ambitious research plan will have a long-term payoff for the streamline of our ability to infer and design dynamic mechanisms, which will be essential for advancing fundamental understanding in biology and developing new medical and industrial applications.

Teaching Interests

BIOL 737 - Research Seminar in Bioinformatics and Computational Biology

BIOL 615 - Systems Biology (graduate)

BIOL 415 - Systems Biology

BIOL 313 - Introduction to Bioinformatics and Computational Biology

Intellectual Contributions

Mousavi, Reza, Konuru, Sri, Lobo, Daniel. (2021). . bbab104. Briefings in Bioinformatics.

Ko, Jason, Mousavi, Reza, Lobo, Daniel. (2021). Computational systems biology of morphogenesis. Computational Systems Biology in Medicine and Biotechnology Springer.

Lobo, Daniel. (2021). Formalizing Phenotypes of Regeneration. Whole Body Regeneration Springer.

Hwang, Jeanice, Hari, Archana, Cheng, Raymond, Gardner, Jeffrey G., Lobo, Daniel. (2020). . 117 3876-3890 Biotechnology and Bioengineering.

Hari, Archana, Lobo, Daniel. (2020). . 48 427-435 Nucleic Acids Research.

Roy, Joy, Cheung, Eric, Bhatti, Junaid, Muneem, Abraar, Lobo, Daniel. (2020). . 9. 36 2881–2887 Bioinformatics.

Ko, Jason M., Lobo, Daniel. (2019). . 11. 117 2166-2179 Biophysical Journal.

Herath, Samantha, Lobo, Daniel. (2019). . 485 110042 Journal of Theoretical Biology.

García-Quismondo, Manuel, Levin, Michael, Lobo, Daniel. (2017). . 381 229–249 Information Sciences.

Lobo, Daniel, Lobikin, Maria, Levin, Michael. (2017). . 7 41339 Scientific Reports.

Lobo, Daniel, Levin, Michael. (2017). . Advances in Unconventional Computing: Emergence, Complexity and Computation 637–654 Switzerland: Springer International Publishing.

Lobo, Daniel, Morokuma, Junji, Levin, Michael. (2016). . 17. 32 2681–2685 Bioinformatics.

Durant, Fallon, Lobo, Daniel, Hammelman, Jennifer, Levin, Michael. (2016). . 2. 3 78–102 Regeneration.

Hammelman, Jennifer, Lobo, Daniel, Levin, Michael. (2016). . Artificial Neural Network Modelling 628 45–65 Springer International Publishing.

Lobo, Daniel, Hammelman, Jennifer, Levin, Michael. (2016). . 4. 23 291–297 Journal of Computational Biology.

Rubin, Beatrix P., Brockes, Jeremy, Galliot, Brigitte, Grossniklaus, Ueli, Lobo, Daniel, Mainardi, Marco, Mirouze, Marie, Prochiantz, Alain, Steger, Angelika. (2015). . 1288 F1000Research.

Emmons-Bell, Maya, Durant, Fallon, Hammelman, Jennifer, Bessonov, Nicholas, Volpert, Vitaly, Morokuma, Junji, Pinet, Kaylinnette, Adams, Dany, Pietak, Alexis, Lobo, Daniel, Levin, Michael. (2015). . 11. 16 27865–27896 International Journal of Molecular Sciences.

Lobikin, Maria, Lobo, Daniel, Blackiston, Douglas J., Martyniuk, Christopher J., Tkachenko, Elizabeth, Levin, Michael. (2015). . 397. 8 ra99 Science Signaling.