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Achuth Padmanabhan

Assistant Professor

Biological Sciences
Interdisciplinary Life Sciences Building (ILSB), Room 420
Instructor, Baylor College of Medicine (2019)
Postdoc, Yale University (2015)
Ph D, University of Maryland Baltimore County (2011)
BS, Bharathidasan University (2005)
Research Interests

How does a normal cell become cancerous? What factors enable cancer cells to grow rapidly, evade immune surveillance and metastasize to distant sites? How does the tumor microenvironment evolve during this process? Why are the extant anti-cancer therapeutics largely ineffective? How can we develop more effective therapeutic strategies that will improve clinical outcome in patients with metastatic disease? These are some of the broad questions we seek to address in our laboratory.

Teaching Interests

BIOL 444/644 - Development and Cancer

Contracts, Fellowships, Grants, and Sponsored Research

Padmanabhan, Achuth COMMERCIALIZATION & ENTR RESEARCH (CENTRE) FUNDING INITIATIVE Grant Sponsored by Alex. Brown Center for Entrepreneurship at UMBC (Jul 1, 2021 – Jun 30, 2022)

Padmanabhan, Achuth Bieberich, Charles Joseph. (Co-Principal) ENTREPRENEURSHIP & INNOVATION CURRICULUM GRANT Grant Sponsored by University of Maryland Baltimore County (Jul 1, 2021 – Jun 30, 2022)

Padmanabhan, Achuth (Principal) Strategic Awards for Research Transitions (START) Grant Sponsored by University of Maryland Baltimore County (Jul 1, 2021 – Jun 30, 2022)

Padmanabhan, Achuth (Principal) Xue, Fengtian (Co-Principal) Accelerated Translational Incubator Pilot (ATIP) Grant Grant (Funded) Sponsored by University of Maryland, Baltimore (UMB) Institute for Clinical & Translational Research (ICTR) (May 1, 2020 – Apr 30, 2021)

Padmanabhan, Achuth (Principal) American Cancer Society - Institutional Research Grant SubContract (In-Progress) Sponsored by American Cancer Society (Jan 1, 2020 – Dec 31, 2020)

Padmanabhan, Achuth (Principal) Scientific Scholar Award Sponsored Research (In-Progress) Sponsored by Rivkin Center for Ovarian Cancer (Sep 1, 2019 – Aug 31, 2021)

Intellectual Contributions

Zinc Oxide nanoparticles induce oxidative and proteotoxic stress in ovarian cancer cells and trigger apoptosis Independent of p53-mutation status vol. 487 807-818 Applied surface science

VCAM1 Is Induced in Ovarian Theca and Stromal Cells in a Mouse Model of Androgen Excess 6 vol. 160 1377-1393 Endocrinology

Selective targeting of p53 gain-of-function mutants in cancer 3-4 vol. 5 73-74 Oncoscience

USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells 1 vol. 9 1270 Nature Communications

Regulating NKX3.1 stability and function: Post-translational modifications and structural determinants 6 vol. 76 523-33 The Prostate

Assembly of an Evolutionarily Conserved Alternative Proteasome Isoform in Human Cells 12 vol. 14 2962-74 Cell Reports

Protein kinase A regulates MYC protein through transcriptional and post-translational mechanisms in a catalytic subunit isoform-specific manner 20 vol. 288 14158-69 The Journal of biological chemistry

Stabilization of the prostate-specific tumor suppressor NKX3.1 by the oncogenic protein kinase Pim-1 in prostate cancer cells 5 vol. 114 1050-7 Journal of cellular biochemistry

The reverse in-gel kinase assay to profile physiological kinase substrates 11 vol. 4 957-62 Nature Methods