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Michelle Starz-Gaiano

Associate Professor

Biological Sciences
Biological Sciences Bldg, Room BS 212
Ph D, New York University School of Medicine (2002)
BS, Massachusetts Institute of Technology (1994)

Postdoctoral: Johns Hopkins School of Medicine, D. Montell laboratory
Ph.D.: New York University, Developmental Genetics, R. Lehmann laboratory
B.S.: Massachusetts Institute of Technology, Biology

Research Interests

How do complex organs form during animal development? We are working to identify the signaling events that enable cells to migrate, interact, and contribute to tissue architecture. We use Drosophila genetics, molecular biology, imaging, and interdisciplinary approaches. In particular, our research group focuses on understanding the regulation of the well-conserved Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) pathway and steroid hormone signaling.

Teaching Interests

Cell Biology, Developmental Genetics, Eukaryotic Molecular Genetics, Biomathematics. Evidence-based improvements in pedagogy.

Selected Classes
Fall 2020 BIOL 303 – Cell Biology
Spring 2020 BIOL 414 – Eukaryotic Molecular Genetics
Fall 2016 BIOL 303 – Cell Biology
Spring 2016 BIOL 414 – Eukaryotics Gen/Mol Biol
BIOL 614 – Gen & Euk Mol Biol
Contracts, Fellowships, Grants, and Sponsored Research

Starz-Gaiano, Michelle Starz-Gaiano, Michelle Regulation and function of STAT signaling in cell adhesion Grant (Funded) Sponsored by NSF, Biological Sciences IOS (Feb 15, 2011 – Jan 31, 2017)

Intellectual Contributions

Development and Analysis of a Quantitative Mathematical Model of Bistability in the Cross Repression System Between APT and SLBO Within the JAK/STAT Signaling Pathway. vol. 11 803 Frontiers in physiology

Clustered cell migration: Modeling the model system of Drosophila border cells. vol. 100 167-176 Seminars in cell & developmental biology


Lisinopril Preserves Physical Resilience and Extends Life Span in a Genotype-Specific Manner in Drosophila melanogaster 12 vol. 74 1844-1852 JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Drosophila Jak/STAT Signaling: Regulation and Relevance in Human Cancer and Metastasis. Special Issue: Drosophila models of human disease 12 vol. 19 International journal of molecular sciences

Cytokine exocytosis and JAK/STAT activation in the Drosophila ovary requires the vesicle trafficking regulator α-Snap. vol. 131 Journal of Cell Science

A hormonal cue promotes timely follicle cell migration by modulating transcription profiles. vol. 148 56-68 Mechanisms of development

Circuitous genetic regulation governs a straightforward cell migration 10 vol. 32 660-73 Cambridge MA Trends in Genetics

Identification of Novel Regulators of the JAK/STAT Signaling Pathway in Border Cell Migration in the Drosophila Ovary 7 vol. 6 1991-2002 Bethesda G3

Apontic regulates somatic stem cell numbers in Drosophila testes 1 vol. 16 doi: 10.1186/s12861-016-0103-3. BMC Developmental Biology

Socs36E limits STAT signaling via Cullin2 and a SOCS-box independent mechanism in the Drosophila egg chamber 3 vol. 138 313-27 Mechanisms of Development

Tissue landscape alters adjacent cell fates during Drosophila egg development. vol. 6 7356 Nature communications

4 vol. 10 e0122799 PloS one

Upright imaging of Drosophila egg chambers doi: 10.3791/52636 vol. 97 Journal of Visualized Experiments

Culturing Egg Chambers and Investigating Developmental Processes through Live Imaging. Drosophila oogenesis: Methods in Molecular Biology Series Springer

Phagocytic ability declines with age in adult Drosophila hemocytes vol. 13 719-728 Aging Cell

Group Choreography: Molecular Mechanisms Orchestrating the Collective Movement of Border Cells vol. 13 631-645 Nature Reviews Molecular Cell Biology

1 vol. 5 1-21 AIMS Biophysics


(Author) (Author) Society of Mathematical Biology Annual Meeting Oral Presentation A Minimal Model for STAT regulation in Initiation of Clustered Border Cell Migration. Society of Mathematical Biology Online