Research Assistant Professor
Biological Sciences Bldg 211
Ph D Teikyo University School of Medicine 1993
Doctoral Degree Program Niigata University School of Medicine 1987
MS Niigata University 1985
BS Niigata University 1983
+1 410 455 8674
Our research investigates chemical senses using methods of electrophysiology, functional imaging, immunocytochemistry, and behavior assay in transgenic mice. Current research focus is to elucidate effects of acute and long term exposure to environmental chemicals causing irritation on the chemosensory system including olfactory and trigeminal systems and to find out how the systems maintain the sensory functions during the chemical challenges adapting the environmental changes.
Ni, Fenge, Ogura, Tatsuya, Lin, Weihong. (2020). Electronic Cigarette Liquid Constituents Induce Nasal and Tracheal Sensory Irritation in Mice in Regionally Dependent Fashion. Suppl_1. 22 S35-S-44 Nicotine & Tobacco Research.
Lemons, Kayla, FU, Ziying, Ogura, Tatsuya, Lin, Weihong. (2020). TRPM5-expressing Microvillous Cells Regulate Region-specific Cell Proliferation and Apoptosis During Chemical Exposure. 434 171-190 Neuroscience.
AlMatrouk, Abdullah, Ogura, Tatsuya, Luo, Wangmei, Wilson, Chantel, Lin, Weihong. (2018). Mice lacking transient receptor potential channel M5-expressing microvillous cells show different changes in the expression of neurotrophins and their receptors in the main olfactory system in response to chemical exposure. 10. 19 2939 International Journal of Molecular Sciences.
Fu, Ziying, Ogura, Tatsuya, Luo, Wangmei, Lin, Weihong. (2018). ATP and odor mixture activate TRPM5-expressing microvillous cells and potentially induce acetylcholine release to enhance supporting cell endocytosis in mouse main olfactory epithelium. 71. 12 doi: 10.3389/fncel.2018.0007 Front. Cell. Neurosci..
Lemons, Kayla, Fu, Ziying, Aoude, Imad, Ogura, Tatsuya, Sun, Julianna, Chang, Justin, Mbonu, Kenechukwu, Ohmoto, Makoto, Matsumoto, Ichiro, Arakawa, Hiroyuki, Lin, Weihong. (2017). Lack of TRPM5-expressing microvillous cells in mouse main olfactory epithelium leads to impaired odor-evoked responses and olfactory-guided behavior in a challenged chemical environment. 4 (3) ENEURO.0135-17.2017 eNeuro.
Marking, S, Krosnowski, K, Ogura, Tatsuya, Lin, Weihong. (2017). Dichotomous Distribution of Putative Cholinergic Interneurons in Mouse Accessory Olfactory Bulb. 11 10 Frontiers in neuroanatomy.
Szebenyi, S A., Ogura, Tatsuya, Sathyanesan, Aaron, AlMatrouk, Abdullah K., Chang, J, Lin, Weihong. (2014). Increases in intracellular calcium via activation of potentially multiple phospholipase C isozymes in mouse olfactory neurons. doi: 10.3389/fncel.2014.00336 Frontiers Cellular Neurosciences.
Yamaguchi, T, Yamashita, J, Ohmoto, M, Aoudé, I, Ogura, Tatsuya, Luo, Wangmei, Bachmanov, A A., Lin, Weihong, Matsumoto, I, Hirota, J. (2014). Skn-1a/Pou2f3 is required for the generation of Trpm5-expressing microvillous cells in the mouse main olfactory epithelium. 15 13 doi: 10.1186/1471-2202-15-13 BMC neuroscience.
Dunston, D, Ashby, S, Krosnowski, K, Ogura, Tatsuya, Lin, Weihong. (2013). An effective manual deboning method to prepare intact mouse nasal tissue with preserved anatomical organization. 78. doi: 10.3791/50538. Journal of visualized experiments : JoVE.
Sathyanesan, A, Ogura, Tatsuya, Lin, Weihong. (2012). Automated measurement of nerve fiber density using line intensity scan analysis. 206(2) 165-75 J Neurosci Methods.
Krosnowski, K, Ashby, S, Sathyanesan, A, Luo, W, Ogura, Tatsuya, Lin, Weihong. (2012). Diverse populations of intrinsic cholinergic interneurons in the mouse olfactory bulb. Image was selected for Cover page 213 161-78 Neurosci.
Ogura, Tatsuya, Szebenyi, SA, Krosnowski, K, Sathyanesan, A, Jackson, J, Lin, Weihong. (2011). Cholinergic microvillous cells in the mouse main olfactory epithelium and effect of acetylcholine on olfactory sensory neurons and supporting cells. 106(3) 1274-87 J Neurophysiol.
Ogura, Tatsuya, Krosnowski, K, Zhang, L, Bekkerman, M, Lin, Weihong. (2010). Chemoreception regulates chemical access to mouse vomeronasal organ: Role of solitary chemosensory cells. 5(7) 11924 PLoS One.
Ikenaga, T, Ogura, Tatsuya, Finger, TE. (2009). Vagal gustatory reflex circuits for intraoral food sorting behavior in the goldfish: Cellular organization and neurotransmitters. J Comp Neurol. 516 213-225
Lin, Weihong, Ogura, Tatsuya, Margoleskee, RF, Finger, TE, Restrepo, D. (2008). TRPM5-expressing solitary chemosensory cells respond to odorous irritants. Selected as News Topics by the American Physiological Society, and by NIH 99(3) 1451-60 J Neurophysiol.
Ogura, Tatsuya, Margolskee, RF, Tallini, YF, Shui, B, Kotlikoff, MI, Lin, W. (2007). Immuno-localization of Vesicular Acetylcholine Transporter in Mouse Taste Cells and Adjacent Nerve Fibers: Indication of Acetylcholine Release. 330(1) 17-28 Cell Tissue Res.
Ogura, Tatsuya, Lin, Weihong. (2005). Acetylcholine and acetylcholine receptors in taste receptor cells. Chemical Senses. 30 i41
Kataoka, S, Toyono, T, Seta, Y, Ogura, Tatsuya, Toyoshima, K. (2004). Expression of P2Y1 receptors in rat taste buds. Histochem. Cell Biol. 121 419-426
Ogura, Tatsuya, Warasinha, A, Inoue, M. (2004). A chromaffin cell model to simulate calcium dynamics and secretory responses in various conditions. In “Cell Biology of the Chromaffin Cell”. 203-210 eds. R. Borges & L. Gandía. Publ. University of La Laguna, Spain.
Ogura, Tatsuya, Warashina, A. (2004). Modeling of stimulation-secretion coupling in a chromaffin cell. Pluger Arc Eur J Physiol. 448(2) 161-74
Perez, CA, Margolskee, RF, Kinnamon, SC, Ogura, Tatsuya. (2003). Making sense with TRP channels: Store-operated calcium entry and the ion channel Trpm5 in taste receptor cells. Cell Calcium. 33 541-549
Lin, Weihong, Ogura, Tatsuya, Kinnamon, SC. (2003). Responses to di-sodium guanosine 5’-monophosphate and monosodium L-glutamate in taste receptor cells of rat fungiform papillae. First two authors contributed equally to the work 89(3) 1434-9 J Neurophysiol.
Lin, Weihong, Ogura, Tatsuya, Kinnamon, SC. (2002). Acid-activated cation currents in rat vallate taste receptor cells. 88(1) 133-41 J. Neurophysiol.
Ogura, Tatsuya, Margolskee, RF, Kinnamon, SC. (2002). Taste receptor cell responses to the bitter stimulus denatonium involve Ca2+ influx via store-operated channels. J. Neurophysiol. 87(6) 3152-5
Ogura, Tatsuya. (2002). Acetylcholine increases intracellular Ca2+ in taste cells via activation of muscarinic receptors. J. Neurophysiol. 87(6) 2643-9
Ruize, JC, Leslie, MS, McPheeters, M, Ogura, Tatsuya, Bottger, B, Lasher, RS, Finger, TE, Kinnamon, SC. (2001). Maintenance of rat taste buds in primary culture. Chemical Senses. 26(7) 861-73
Varkevisser, B, Peterson, D, Ogura, Tatsuya, Kinnamon, SC. (2001). Neural networks distinguish between taste qualities based on receptor cell population responses. Chemical Senses. 26(5) 499-505
Ogura, Tatsuya, Kinnamon, SC. (1999). IP3-independent release of Ca2+ from intracellular stores: A novel mechanism for transduction for bitter stimuli. J Neurophys. 82 2657-2666
Nakai, J, Ogura, Tatsuya, Protasi, F, Franzini-Armstrong, C, Allen, PD, Beam, KG. (1997). Functional nonequality of the cardiac and skeletal ryanodine receptors. Proc Natl Acad Sci USA. 94 1019-1022
Ogura, Tatsuya, Mackay-Sim, AA, Kinnamon, SC. (1997). Bitter taste transduction of denatonium in the mudpuppy, Necturus maculosus. J Neurosci. 17(10) 3580-3587
Ogura, Tatsuya, Obara, S. (1993). Chloride current observed as calcium-gated tail current in trigeminal ganglion neurons of the marine catfish, Plotosus. Brain Res. 621 10-16
Ogura, Tatsuya, Obara, S. (1992). The membrane properties and Ca-currents of the trigeminal root ganglion cells in primary culture of the marine catfish, Plotosus, studied with whole-cell recordings. Brain Res. 597 84-91
Warasinha, A, Ogura, Tatsuya, Fujitha, S. (1988). Binding Properties of Sea Anemone Toxins to Sodium Channels in the Crayfish Giant Axon. Comp Biochem Physiol. 90(2) 351-9
Ogura, Tatsuya, Warashina, A. (1988). Effects of histrionicotoxin derivatives on ion channels and acetylcholine receptor-channel complexes in bullfrog sympathetic ganglia. Comp Biochem Physiol. 88c 245-54
Warashina, A, Jiang, Z-Y, Ogura, Tatsuya. (1988). Potential-dependent action of Anemonia sulcata toxins III and IV on sodium channels in crayfish giant axons. Pflugers Arch -Eur J Physiol. 411 88-93
Ogura, Tatsuya, Irie, T, Usuki, T. (1985). Respiratory inhibition by cyanide and salicylhydroxamic acid on the three species of Paramecium in stationary growth phase. Comp Biochem Physiol. 80A 167-171
AlMatrouk, Abdullah, Lemons, Kayla, Ogura, Tatsuya, Lin, Weihong. Modification of the Peripheral Olfactory System by Electronic Cigarettes.. Comprehensive Physiology.