Research Interests

Our research investigates chemical senses using methods of electrophysiology, functional imaging, immunocytochemistry, and behavior assay in transgenic mice. Current research focus is to elucidate effects of acute and long term exposure to environmental chemicals causing irritation on the chemosensory system including olfactory and trigeminal systems and to find out how the systems maintain the sensory functions during the chemical challenges adapting the environmental changes.

Intellectual Contributions

AlMatrouk, Abdullah Ogura, Tatsuya Luo, Wangmei Wilson, Chantel Lin, Weihong (2018) Mice lacking transient receptor potential channel M5-expressing microvillous cells show different changes in the expression of neurotrophins and their receptors in the main olfactory system in response to chemical exposure 10 vol. 19 2939 International Journal of Molecular Sciences

Fu, Ziying Ogura, Tatsuya Luo, Wangmei Lin, Weihong (2018) ATP and odor mixture activate TRPM5-expressing microvillous cells and potentially induce acetylcholine release to enhance supporting cell endocytosis in mouse main olfactory epithelium 71 vol. 12 doi: 10.3389/fncel.2018.0007 Front. Cell. Neurosci.

Lemons, Kayla Fu, Ziying Aoude, Imad Ogura, Tatsuya Sun, Julianna Chang, Justin Mbonu, Kenechukwu Ohmoto, Makoto Matsumoto, Ichiro Arakawa, Hiroyuki Lin, Weihong (2017) Lack of TRPM5-expressing microvillous cells in mouse main olfactory epithelium leads to impaired odor-evoked responses and olfactory-guided behavior in a challenged chemical environment vol. 4 (3) ENEURO.0135-17.2017 eNeuro

Marking, S Krosnowski, K Ogura, Tatsuya Lin, Weihong (2017) Dichotomous Distribution of Putative Cholinergic Interneurons in Mouse Accessory Olfactory Bulb vol. 11 10 Frontiers in neuroanatomy

Szebenyi, S A. Ogura, Tatsuya Sathyanesan, Aaron AlMatrouk, Abdullah K. Chang, J Lin, Weihong (2014) Increases in intracellular calcium via activation of potentially multiple phospholipase C isozymes in mouse olfactory neurons doi: 10.3389/fncel.2014.00336 Frontiers Cellular Neurosciences

Yamaguchi, T Yamashita, J Ohmoto, M Aoudé, I Ogura, Tatsuya Luo, Wangmei Bachmanov, A A. Lin, Weihong Matsumoto, I Hirota, J (2014) Skn-1a/Pou2f3 is required for the generation of Trpm5-expressing microvillous cells in the mouse main olfactory epithelium vol. 15 13 doi: 10.1186/1471-2202-15-13 BMC neuroscience

Dunston, D Ashby, S Krosnowski, K Ogura, Tatsuya Lin, Weihong (2013) An effective manual deboning method to prepare intact mouse nasal tissue with preserved anatomical organization 78 doi: 10.3791/50538. Journal of visualized experiments : JoVE

Sathyanesan, A Ogura, Tatsuya Lin, Weihong (2012) Automated measurement of nerve fiber density using line intensity scan analysis vol. 206(2) 165-75 J Neurosci Methods

Krosnowski, K Ashby, S Sathyanesan, A Luo, W Ogura, Tatsuya Lin, Weihong (2012) Diverse populations of intrinsic cholinergic interneurons in the mouse olfactory bulb Image was selected for Cover page vol. 213 161-78 Neurosci

Ogura, Tatsuya Szebenyi, SA Krosnowski, K Sathyanesan, A Jackson, J Lin, Weihong (2011) Cholinergic microvillous cells in the mouse main olfactory epithelium and effect of acetylcholine on olfactory sensory neurons and supporting cells vol. 106(3) 1274-87 J Neurophysiol

Ogura, Tatsuya Krosnowski, K Zhang, L Bekkerman, M Lin, Weihong (2010) Chemoreception regulates chemical access to mouse vomeronasal organ: Role of solitary chemosensory cells vol. 5(7) 11924 PLoS One

Ikenaga, T Ogura, Tatsuya Finger, TE (2009) Vagal gustatory reflex circuits for intraoral food sorting behavior in the goldfish: Cellular organization and neurotransmitters. J Comp Neurol vol. 516 213-225

Lin, Weihong Ogura, Tatsuya Margoleskee, RF Finger, TE Restrepo, D (2008) TRPM5-expressing solitary chemosensory cells respond to odorous irritants Selected as News Topics by the American Physiological Society, and by NIH vol. 99(3) 1451-60 J Neurophysiol

Ogura, Tatsuya Margolskee, RF Tallini, YF Shui, B Kotlikoff, MI Lin, W (2007) Immuno-localization of Vesicular Acetylcholine Transporter in Mouse Taste Cells and Adjacent Nerve Fibers: Indication of Acetylcholine Release vol. 330(1) 17-28 Cell Tissue Res

Ogura, Tatsuya Lin, Weihong (2005) Acetylcholine and acetylcholine receptors in taste receptor cells. Chemical Senses vol. 30 i41

Ogura, Tatsuya Warashina, A (2004) Modeling of stimulation-secretion coupling in a chromaffin cell. Pluger Arc Eur J Physiol vol. 448(2) 161-74

Kataoka, S Toyono, T Seta, Y Ogura, Tatsuya Toyoshima, K (2004) Expression of P2Y1 receptors in rat taste buds. Histochem. Cell Biol vol. 121 419-426

Ogura, Tatsuya Warasinha, A Inoue, M (2004) A chromaffin cell model to simulate calcium dynamics and secretory responses in various conditions. In “Cell Biology of the Chromaffin Cell” 203-210 eds. R. Borges & L. Gandía. Publ. University of La Laguna, Spain

Perez, CA Margolskee, RF Kinnamon, SC Ogura, Tatsuya (2003) Making sense with TRP channels: Store-operated calcium entry and the ion channel Trpm5 in taste receptor cells. Cell Calcium vol. 33 541-549

Lin, Weihong Ogura, Tatsuya Kinnamon, SC (2003) Responses to di-sodium guanosine 5’-monophosphate and monosodium L-glutamate in taste receptor cells of rat fungiform papillae First two authors contributed equally to the work vol. 89(3) 1434-9 J Neurophysiol

Ogura, Tatsuya (2002) Acetylcholine increases intracellular Ca2+ in taste cells via activation of muscarinic receptors. J. Neurophysiol vol. 87(6) 2643-9

Lin, Weihong Ogura, Tatsuya Kinnamon, SC (2002) Acid-activated cation currents in rat vallate taste receptor cells vol. 88(1) 133-41 J. Neurophysiol

Ogura, Tatsuya Margolskee, RF Kinnamon, SC (2002) Taste receptor cell responses to the bitter stimulus denatonium involve Ca2+ influx via store-operated channels. J. Neurophysiol vol. 87(6) 3152-5

Ruize, JC Leslie, MS McPheeters, M Ogura, Tatsuya Bottger, B Lasher, RS Finger, TE Kinnamon, SC (2001) Maintenance of rat taste buds in primary culture. Chemical Senses vol. 26(7) 861-73

Varkevisser, B Peterson, D Ogura, Tatsuya Kinnamon, SC (2001) Neural networks distinguish between taste qualities based on receptor cell population responses. Chemical Senses vol. 26(5) 499-505

Ogura, Tatsuya Kinnamon, SC (1999) IP3-independent release of Ca2+ from intracellular stores: A novel mechanism for transduction for bitter stimuli. J Neurophys vol. 82 2657-2666

Ogura, Tatsuya Mackay-Sim, AA Kinnamon, SC (1997) Bitter taste transduction of denatonium in the mudpuppy, Necturus maculosus. J Neurosci vol. 17(10) 3580-3587

Nakai, J Ogura, Tatsuya Protasi, F Franzini-Armstrong, C Allen, PD Beam, KG (1997) Functional nonequality of the cardiac and skeletal ryanodine receptors. Proc Natl Acad Sci USA vol. 94 1019-1022

Ogura, Tatsuya Obara, S (1993) Chloride current observed as calcium-gated tail current in trigeminal ganglion neurons of the marine catfish, Plotosus. Brain Res vol. 621 10-16

Ogura, Tatsuya Obara, S (1992) The membrane properties and Ca-currents of the trigeminal root ganglion cells in primary culture of the marine catfish, Plotosus, studied with whole-cell recordings. Brain Res vol. 597 84-91

Warasinha, A Ogura, Tatsuya Fujitha, S (1988) Binding Properties of Sea Anemone Toxins to Sodium Channels in the Crayfish Giant Axon. Comp Biochem Physiol vol. 90(2) 351-9

Ogura, Tatsuya Warashina, A (1988) Effects of histrionicotoxin derivatives on ion channels and acetylcholine receptor-channel complexes in bullfrog sympathetic ganglia. Comp Biochem Physiol vol. 88c 245-54

Warashina, A Jiang, Z-Y Ogura, Tatsuya (1988) Potential-dependent action of Anemonia sulcata toxins III and IV on sodium channels in crayfish giant axons. Pflugers Arch -Eur J Physiol vol. 411 88-93

Ogura, Tatsuya Irie, T Usuki, T (1985) Respiratory inhibition by cyanide and salicylhydroxamic acid on the three species of Paramecium in stationary growth phase. Comp Biochem Physiol vol. 80A 167-171

Presentations

Wilson, Chantel (Author & Presenter) AlMatrouk, Abdullah (Author) Ogura, Tatsuya Lin, Weihong (Author) 21th Annual undergraduate Research and Creative Achievement Day Poster Methimazole-Induced Changes to the Main Olfactory Epithelium and Olfactory Bulb in Wildtype and Skn-1a Knockout Mice UMBC (Apr 1, 2017)