Tatsuya Ogura
Research Assistant Professor
Phone |
410-455-8674
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tatsuya@umbc.edu | |
Education |
Ph D, Teikyo University School of Medicine (1993)
Niigata University School of Medicine (1987)
MS, Niigata University (1985)
BS, Niigata University (1983)
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Research Interests
Our research investigates chemical senses using methods of electrophysiology, functional imaging, immunocytochemistry, and behavior assay in transgenic mice. Current research focus is to elucidate effects of acute and long term exposure to environmental chemicals causing irritation on the chemosensory system including olfactory and trigeminal systems and to find out how the systems maintain the sensory functions during the chemical challenges adapting the environmental changes.
Intellectual Contributions
(2020) Electronic Cigarette Liquid Constituents Induce Nasal and Tracheal Sensory Irritation in Mice in Regionally Dependent Fashion Nicotine & Tobacco Research
(2020) TRPM5-expressing Microvillous Cells Regulate Region-specific Cell Proliferation and Apoptosis During Chemical Exposure Neuroscience
(2018) Mice lacking transient receptor potential channel M5-expressing microvillous cells show different changes in the expression of neurotrophins and their receptors in the main olfactory system in response to chemical exposure International Journal of Molecular Sciences
(2018) ATP and odor mixture activate TRPM5-expressing microvillous cells and potentially induce acetylcholine release to enhance supporting cell endocytosis in mouse main olfactory epithelium Front. Cell. Neurosci.
(2017) Dichotomous Distribution of Putative Cholinergic Interneurons in Mouse Accessory Olfactory Bulb Frontiers in neuroanatomy
(2014) Increases in intracellular calcium via activation of potentially multiple phospholipase C isozymes in mouse olfactory neurons Frontiers Cellular Neurosciences
(2014) Skn-1a/Pou2f3 is required for the generation of Trpm5-expressing microvillous cells in the mouse main olfactory epithelium BMC neuroscience
(2013) An effective manual deboning method to prepare intact mouse nasal tissue with preserved anatomical organization Journal of visualized experiments : JoVE
(2012) Automated measurement of nerve fiber density using line intensity scan analysis J Neurosci Methods
(2012) Diverse populations of intrinsic cholinergic interneurons in the mouse olfactory bulb Image was selected for Cover page Neurosci
(2011) Cholinergic microvillous cells in the mouse main olfactory epithelium and effect of acetylcholine on olfactory sensory neurons and supporting cells J Neurophysiol
(2010) Chemoreception regulates chemical access to mouse vomeronasal organ: Role of solitary chemosensory cells PLoS One
(2008) TRPM5-expressing solitary chemosensory cells respond to odorous irritants Selected as News Topics by the American Physiological Society, and by NIH J Neurophysiol
(2007) Immuno-localization of Vesicular Acetylcholine Transporter in Mouse Taste Cells and Adjacent Nerve Fibers: Indication of Acetylcholine Release Cell Tissue Res
(2005) Acetylcholine and acetylcholine receptors in taste receptor cells. Chemical Senses
(2004) Modeling of stimulation-secretion coupling in a chromaffin cell. Pluger Arc Eur J Physiol
(2004) Expression of P2Y1 receptors in rat taste buds. Histochem. Cell Biol
(2004) A chromaffin cell model to simulate calcium dynamics and secretory responses in various conditions. In “Cell Biology of the Chromaffin Cell” eds. R. Borges & L. Gandía. Publ. University of La Laguna, Spain
(2003) Responses to di-sodium guanosine 5’-monophosphate and monosodium L-glutamate in taste receptor cells of rat fungiform papillae First two authors contributed equally to the work J Neurophysiol
(2002) Acid-activated cation currents in rat vallate taste receptor cells J. Neurophysiol
(2001) Maintenance of rat taste buds in primary culture. Chemical Senses
(1997) Bitter taste transduction of denatonium in the mudpuppy, Necturus maculosus. J Neurosci
(1997) Functional nonequality of the cardiac and skeletal ryanodine receptors. Proc Natl Acad Sci USA
Presentations
21th Annual undergraduate Research and Creative Achievement Day Poster Methimazole-Induced Changes to the Main Olfactory Epithelium and Olfactory Bulb in Wildtype and Skn-1a Knockout Mice UMBC (Apr 1, 2017)