Interdisciplinary Life Sciences Building (ILSB) 422
Postdoc University of Colorado Health Sciences Center 2003
Postdoc Colorado State University 2000
Ph D Colorado State University 1999
MS Zhongshan University 1988
BS Zhongshan University 1982
Our lab research is focused on understanding the neurobiological aspects of chemical sensory systems in the nose, specifically mechanisms of sensory detection and functional maintenance. We use transgenic and genetically modified animals and multiple experimental approaches, including intracellular calcium imaging, electrophysiological recordings, immunolabeling, molecular analyses, and behavioral assays in our study. We hope to provide knowledge about: 1) sensory detection of certain chemical substances, such as flavors and other constituents in electronic cigarettes; 2) modulatory networks that adaptively maintain olfactory functions; and 3) environmental exposure-induced sensory dysfunction and associated behavioral deficits.
BIOL 451/651: Neurobiology
BIOL 303: Cell Biology
BIOL 490/690: Chemical Communication and Brain Disorders
BIOL 305: Comparative Animal Physiology
BIOL 499 or 499H: Undergrad Research experience
BIOL 499L: Undergrad Lab Research
BIOL 396: Undergraduate Teaching Assistantship
AlMatrouk, Abdullah, Lemons, Kayla, Ogura, Tatsuya, Lin, Weihong. (2021). Modification of the Peripheral Olfactory System by Electronic Cigarettes.. 4. 11 2621-2644 Comprehensive Physiology.
Ni, Fenge, Ogura, Tatsuya, Lin, Weihong. (2020). Electronic Cigarette Liquid Constituents Induce Nasal and Tracheal Sensory Irritation in Mice in Regionally Dependent Fashion. Suppl_1. 22 S35-S-44 Nicotine & Tobacco Research.
Kenney, Rakaia, Lemons, Kayla, Lin, Weihong. (2020). What makes something smell good or bad?. The Conversation.
Lemons, Kayla, FU, Ziying, Ogura, Tatsuya, Lin, Weihong. (2020). TRPM5-expressing Microvillous Cells Regulate Region-specific Cell Proliferation and Apoptosis During Chemical Exposure. 434 171-190 Neuroscience.
Kenney, Rakaia, Lin, Weihong. (2020). E-cig flavors may be more than alluring; they could cause damage themselves. The Conversation.
AlMatrouk, Abdullah, Ogura, Tatsuya, Luo, Wangmei, Wilson, Chantel, Lin, Weihong. (2018). Mice lacking transient receptor potential channel M5-expressing microvillous cells show different changes in the expression of neurotrophins and their receptors in the main olfactory system in response to chemical exposure. 10. 19 2939 International Journal of Molecular Sciences.
Fu, Ziying, Ogura, Tatsuya, Luo, Wangmei, Lin, Weihong. (2018). ATP and odor mixture activate TRPM5-expressing microvillous cells and potentially induce acetylcholine release to enhance supporting cell endocytosis in mouse main olfactory epithelium. 71. 12 doi: 10.3389/fncel.2018.0007 Front. Cell. Neurosci..
Lemons, Kayla, Fu, Ziying, Aoude, Imad, Ogura, Tatsuya, Sun, Julianna, Chang, Justin, Mbonu, Kenechukwu, Ohmoto, Makoto, Matsumoto, Ichiro, Arakawa, Hiroyuki, Lin, Weihong. (2017). Lack of TRPM5-expressing microvillous cells in mouse main olfactory epithelium leads to impaired odor-evoked responses and olfactory-guided behavior in a challenged chemical environment. 4 (3) ENEURO.0135-17.2017 eNeuro.
Oboti, L, Trova, S, Schellino, R, Marraudino, M, Harris, Natalie R., Abiona, Olubukola M., Stampar, M, Lin, Weihong, Peretto, P. (2017). Activity Dependent Modulation of Granule Cell Survival in the Accessory Olfactory Bulb at Puberty. doi.org/10.3389/fnana.2017.00044 Frontier in Neuroanatomy.
Marking, S, Krosnowski, K, Ogura, Tatsuya, Lin, Weihong. (2017). Dichotomous Distribution of Putative Cholinergic Interneurons in Mouse Accessory Olfactory Bulb. 11 10 Frontiers in neuroanatomy.
Restrepo, Diego, Delay, Delay Rona, Lin, Weihong, López, López F, Bacigalupo, J. (2015). TRP Channels in Transduction for Responses to Odorants and Pheromones. TRP channels in sensory transduction 111-125 Springer International Publishing.
Szebenyi, S A., Ogura, Tatsuya, Sathyanesan, Aaron, AlMatrouk, Abdullah K., Chang, J, Lin, Weihong. (2014). Increases in intracellular calcium via activation of potentially multiple phospholipase C isozymes in mouse olfactory neurons. doi: 10.3389/fncel.2014.00336 Frontiers Cellular Neurosciences.
Yamaguchi, T, Yamashita, J, Ohmoto, M, Aoudé, I, Ogura, Tatsuya, Luo, Wangmei, Bachmanov, A A., Lin, Weihong, Matsumoto, I, Hirota, J. (2014). Skn-1a/Pou2f3 is required for the generation of Trpm5-expressing microvillous cells in the mouse main olfactory epithelium. 15 13 doi: 10.1186/1471-2202-15-13 BMC neuroscience.
Dunston, D, Ashby, S, Krosnowski, K, Ogura, Tatsuya, Lin, Weihong. (2013). An effective manual deboning method to prepare intact mouse nasal tissue with preserved anatomical organization. 78. doi: 10.3791/50538. Journal of visualized experiments : JoVE.
Sathyanesan, A, Feijoo, A A., Mehta, S T., Nimarko, A F., Lin, Weihong. (2013). Expression profile of G-protein βγ subunit gene transcripts in the mouse olfactory sensory epithelia. 84. 7 doi: 10.3389/fncel.2013.00084 Frontiers in Cellular Neuroscience.
Sathyanesan, A, Ogura, Tatsuya, Lin, Weihong. (2012). Automated measurement of nerve fiber density using line intensity scan analysis. 206(2) 165-75 J Neurosci Methods.
Krosnowski, K, Ashby, S, Sathyanesan, A, Luo, W, Ogura, Tatsuya, Lin, Weihong. (2012). Diverse populations of intrinsic cholinergic interneurons in the mouse olfactory bulb. Image was selected for Cover page 213 161-78 Neurosci.
Ogura, Tatsuya, Szebenyi, SA, Krosnowski, K, Sathyanesan, A, Jackson, J, Lin, Weihong. (2011). Cholinergic microvillous cells in the mouse main olfactory epithelium and effect of acetylcholine on olfactory sensory neurons and supporting cells. 106(3) 1274-87 J Neurophysiol.
Ogura, Tatsuya, Krosnowski, K, Zhang, L, Bekkerman, M, Lin, Weihong. (2010). Chemoreception regulates chemical access to mouse vomeronasal organ: Role of solitary chemosensory cells. 5(7) 11924 PLoS One.
Slotnick, B, Restrepo, D, Schellinck, H, Archbold, G, Price, S, Lin, Weihong. (2010). Accessory olfactory bulb function is modulated by input from the main olfactory epithelium. 31 1108-16 Eur J Neurosci.
Lin, Weihong, Jr. Ezekwe, EA, Zhao, Z, Liman, ER, Restrepo, D. (2008). TRPM5-expressing microvillous cells in the main olfactory epithelium. 9(1) 114 BMC Neurosci.
Lin, Weihong, Ogura, Tatsuya, Margoleskee, RF, Finger, TE, Restrepo, D. (2008). TRPM5-expressing solitary chemosensory cells respond to odorous irritants. Selected as News Topics by the American Physiological Society, and by NIH 99(3) 1451-60 J Neurophysiol.
Ogura, Tatsuya, Margolskee, RF, Tallini, YF, Shui, B, Kotlikoff, MI, Lin, W. (2007). Immuno-localization of Vesicular Acetylcholine Transporter in Mouse Taste Cells and Adjacent Nerve Fibers: Indication of Acetylcholine Release. 330(1) 17-28 Cell Tissue Res.
Lin, Weihong, Margolskee, RF, Donnert, G, Hell, D. (2007). Olfactory neurons expressing transient receptor potential channel M5 (TRPM5) are involved in sensing semiochemicals. 104(7) 2471-6 Proc Natl Acad Sci USA.
Restrepo, D, Lin, Weihong, Salcedo, E, Yamazaki, K, Beauchamp, G. (2006). Odortypes and MHC peptides: Complementary chemosignals of MHC haplotype?. 29 604-9 Trends in Neuroscience.
Lin, Weihong, Burks, CA, Hansen, DR, Kinnamom, SC, Gilbertson, TA. (2004). Taste receptor cells express pH-sensitive leak K+ channels. 92 2909-19 J Neurophysiol.
Lin, Weihong, Arellano, J, Slotnick, B, Restrepo, D. (2004). Odors detected by mice deficient in cyclic nucleotide-gated channel subunit A2 stimulate the main olfactory system. 24 3703-10 J Neurosci.
Restrepo, D, Arellano, J, Oliva, A, Schaefer, M, Lin, Weihong. (2004). Emerging views on the distinct, but overlapping roles of the main and accessory olfactory systems in responsiveness to chemosensory signals in mice. 46 47-56 Hormones and behavior.
Lin, Weihong, Ogura, Tatsuya, Kinnamon, SC. (2003). Responses to di-sodium guanosine 5’-monophosphate and monosodium L-glutamate in taste receptor cells of rat fungiform papillae. First two authors contributed equally to the work 89(3) 1434-9 J Neurophysiol.
Lin, Weihong, Ogura, Tatsuya, Kinnamon, SC. (2002). Acid-activated cation currents in rat vallate taste receptor cells. 88(1) 133-41 J. Neurophysiol.
Lin, Weihong, Kinnamon, SC. (1999). Co-localization of epithelial sodium channels and glutamate receptors in single taste cells. 8 360-5 Biological Signals and Receptors.
Lin, Weihong, Finger, T, Rossier, BC, Kinnamon, SC. (1999). Epithelial Na+ channel subunits in rat taste cells: Localization and regulation of aldosterone. 405(3) 406-20 J Comp Neurol.
Lin, Weihong, Kinnamon, SC. (1999). Physiological evidence for ionotropic and metabotropic glutamate receptors in rat taste cells. 82 2061-69 J Neurophysiol.
Wladkowski, SL, Lin, Weihong, McPheeters, M, Kinnamon, SC, Mierson, S. (1998). A basolateral chloride conductance in rat lingual epithelium. 164(1) 91-101 J Membrane Biol.
Lin, Weihong. (1998). Responses to monosodium glutamate and guanosine 5’-monophosphate in rat fungiform taste cells. 855 407-11 Ann N Y Acad Sci.
Kossel, AH, McPheeters, M, Lin, Weihong, Kinnamon, SC. (1997). Development of membrane properties in taste cells of fungiform papillae: functional evidence for early presence of amiloride-sensitive sodium channels. 17(24) 9634-41 J Neuroscience.
Krasteva-Christ, Gabriela, Lin, Weihong, Tizzano, Marco. Extraoral taste receptor. The Senses: A Comprehensive Reference, 2nd Edition Academic Press.