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Stephen Freeland

Director of Interdisciplinary Studies

Biological Sciences

Fine Arts 005

Education

Ph D Camrbidge University 1998

MS University of York 1993

BA Oxford University 1991

About

From 1998-2009 I functioned primarily as an individual scientific researcher using computers to study the evolutionary origins of the central dogma of molecular biology. This work continues through a focus to explore alternatives to the "alphabet" of 20 amino acids with which genetic material evolved to encode proteins, early in our planet's history. Current projects include chemical library construction and analysis, Ramachandran plots for oligopeptides composed of xeno amino acids, and 3D printing xeno amino acids.

Since 2009 I have directed increasing effort towards supporting and developing team-based academic projects and programs fcoused on wider questions of astrobiology andabiogenesis

Research Interests

Abiogenesis: Evolutionary chemical informatics, specifically generating and analyzing amino acid structures beyond those known to biology.

Synthetic biology: Creating informatics tools to collate and analyze the mushrooming world of non-coded amino acids that experimentalists ("wet lab" researchers) have already incorporated into protein synthesis.

Broader active interests are the evolution of fundamental biochemistry, astrobiology, abiogenesis and biosignatures.

Teaching Interests

INDS core courses, FYE101

BIOL770: Amino Acid Alphabet Evolution


Intellectual Contributions

Mayer-Bacon, Christopher, Freeland, Stephen. (2021). . 520 110661 Journal of Theoretical Biology.

Boring, Emily, Stump, JB, Freeland, Stephen. (2020). . 1. 72 Perspectives on Science \& Christian Faith.

Jarzynski, Mark, Engel, Donald, Freeland, Stephen, Boot, Lee R., Murnane, Mark, Lindvig, Katrine, Hillersdal, Line, Earle, David. (2020). . Companion of the 2020 ACM International Conference on Supporting Group Work 127-013 New York, NY: Association for Computing Machinery.

Ilardo, Melissa, Bose, Rudrarup, Meringer, Markus, Rasulev, Bakhtiyor, Grefenstette, Natalie, Stephenson, James, Freeland, Stephen, Gillams, Richard J., Butch, Christopher J., Cleaves, H James. (2019). . 1. 9 1--9 Scientific reports.

Ilardo, Melissa, Meringer, Markus, Freeland, Stephen, Rasulev, Bakhtiyor, Cleaves, II, H James. (2015). . 1. 5 1--6 Scientific reports.

Ilardo, Melissa A., Freeland, Stephen. (2014). . 1. 5 1--9 Journal of Systems Chemistry.

Meringer, Markus, Cleaves, H James., Freeland, Stephen. (2013). . 11. 53 2851--2862 Journal of chemical information and modeling.

Stephenson, James D., Freeland, Stephen. (2013). . 4. 77 159--169 Journal of molecular evolution.

Philip, Gayle K., Freeland, Stephen. (2011). . 3. 11 235--240 Astrobiology.

Freeland, Stephen. (2009). . 1 43--75 Amino Acids, Peptides and Proteins in Organic Chemistry: Origins and Synthesis of Amino Acids.

Lu, Yi, Freeland, Stephen. (2008). . 2. 250 349--361 Journal of theoretical biology.

Freeland, Stephen. (2008). . 280 Biochemistry and Fine-Tuning.

Barrow, John D., Morris, Simon Conway., Freeland, Stephen, Harper, Jr, Charles L. (2008). . Biochemistry and fine tuning. Cambridge U. Press.

Lu, Yi, Freeland, Stephen. (2006). . 1. 7 1--6 Genome biology.

Lu, Yi, Freeland, Stephen. (2006). . 4. 6 606--624 Astrobiology.

Zhu, Wen, Freeland, Stephen. (2006). . 1. 239 63--70 Journal of theoretical biology.

Wu, Gang, Wolf, Julie B., Ibrahim, Ameer F., Vadasz, Stephanie, Gunasinghe, Muditha, Freeland, Stephen. (2006). . 3. 124 496--503 Journal of biotechnology.

Knight, Rob D., Freeland, Stephen, Landweber, Laura F. (2004). . The genetic code and the origin of life 201--220 Springer.

Freeland, Stephen, Hurst, Laurence D. (2004). . 4. 290 84--91 Scientific American.

Freeland, Stephen, Wu, Tao, Keulmann, Nick. (2003). . 4. 33 457--477 Origins of Life and Evolution of the Biosphere.

Freeland, Stephen. (2003). . Genetic programming theory and practice 303--311 Springer.

Freeland, Stephen. (2002). . 2. 3 113--127 Genetic Programming and Evolvable Machines.

Knight, Robin D., Freeland, Stephen, Landweber, Laura F. (2001). . 1. 2 49--58 Nature Reviews Genetics.

Freeland, Stephen, Knight, Robin D., Landweber, Laura F. (1999). . 5440. 286 690--692 Science.

Knight, Robin D., Freeland, Stephen, Landweber, Laura F. (1999). . 6. 24 241--247 Trends in biochemical sciences.

Freeland, Stephen, Hurst, Laurence D. (1998). . 3. 47 238--248 Journal of molecular evolution.

Freeland, Stephen, McCABE, BRIDGET K. (1997). . 4. 78 391--402 Heredity.